Before hemodialysis: medical staff should briefly introduce hemodialysis related knowledge and matters needing attention to uremia patients and their families, so as to alleviate the fear of uremia patients and make them mentally prepared to cooperate with treatment. Hemodialysis environment should be quiet, the temperature and humidity are appropriate, the bed is clean and flat, and the lying position is comfortable. Hemodialysis should be carried out by special personnel, and the dialyzer and pipeline should be washed and circulated after inspection. Medical staff should fully understand the general situation, diet, weight gain, intake and output, blood urea nitrogen, creatinine and other bleeding tendencies of uremia patients, and set the hemodialysis time and ultrafiltration volume according to the doctor's advice. Before hemodialysis, medical staff should select suitable blood vessels and disinfect the puncture site, establish vascular access skillfully and skillfully, and inject the first dose of heparin from the venous end of blood vessels.