The departments of UC Irvine include claire trevor Art College, Education College, Paul Merag Business School, Biological Sciences College, Computer Information College, Physics College, Social Ecology College, Social Sciences College, Henry samuels Engineering College, Fine Arts College, Engineering College, Humanities College and Medical College. The main departments include management, humanities, fine arts, information system, earth science, science and technology, biology and medical college.

The majors offered by the school have comparative advantages in computer science, computer engineering, physics, bioengineering, cell biology, mechanical engineering, aerospace engineering, information system, medicine, pharmacy, education, chemistry, criminology, English, sociology, psychology, mathematics, material engineering, environmental engineering and civil engineering. , and business, economics, nursing, law, engineering and life sciences.