The focus of health education is: women over 35 years old should have amniotic fluid cell examination after pregnancy, and pay attention to finding translocation chromosome carriers. Any mother under the age of 30, whose mother has congenital stupidity or has this patient among menstruation sisters, should have her chromosome karyotype checked as soon as possible. Avoid X-ray exposure during pregnancy, and do not abuse drugs to prevent virus infection. The recurrence risk rate of standard 2 1- trisomy syndrome is 1%. The older the mother, the higher the risk rate. Parents of children with translocation should carry out nuclear typing analysis to find balanced translocation carriers, such as maternal-oriented D_G translocation, with a risk rate of 4%. Most cases of G_G translocation are sporadic, and their parents' karyotypes are normal, but 2 1_2 1 translocation carriers have also been found, and their next generation 100% suffer from this disease.