As long as you have the basic knowledge of painting, it is easy to use Wacom graphics tablet. Start with sketching, then learn gouache or watercolor.
Just say that the software may still have the meaning of learning, but you can start painting without learning, installing the software and opening a new file.
Corel Painter is a hand-painted software. Just spend a day learning all kinds of painting tools.
Adobe Photoshop also has powerful painting functions. You can still draw by mastering the preset strokes and the use of color swatches.
In fact, using Wacom pressure sensitive pen, don't feel too mysterious at all. Just like holding a pencil in your hand, with good hand-drawing skills, you will soon get used to the use of graphic tablets and pressure-sensitive pens, which is not so complicated.
I taught myself Painter and the combination of PS and Wacom graphic tablet, and it took me a short time to learn it, and then it was a habit process. I bought Wacom Intous graphics tablet more than ten years ago, and it has been used until now. Since the mouse broke down, I'm not willing to use it now. When I turn on the computer, I can always use the tablet, and the mouse will be an ornament on the table.
Don't worry, I suggest you spend a few weekends thinking for yourself and practice drawing small things in Painter or PS with a pressure-sensitive pen. I believe you will soon be able to master the use of hand-drawn board.
Finally, I wish you good results!