Physiological significance: on the one hand, it can save energy and reduce the consumption of amino acids. On the other hand, it has important physiological significance for some tissues that lack the main synthetic pathway, such as human white blood cells and platelets, brain, bone marrow, spleen and so on. The drug can produce AMP, GMP, etc. , can be converted into ADP, ATP, GDP, GTP.
The recycling route is also called reuse route and regeneration route. In order to meet the needs of organisms, the way to use a part of decomposed organisms and biosynthesize these substances again is a term corresponding to the ab initio way.
For example, in nucleotide biosynthesis, bases and nucleosides of nucleic acid decomposition products are synthesized under the action of phosphoribosyltransferase and nucleotidase, which is a way to play a role in the synthesis of new nucleic acid molecules. In the process of updating their nucleic acids (especially RNA), most cells decompose nucleic acids to produce nucleosides and free bases. The process that cells synthesize corresponding nucleotides by using free bases or nucleosides is called salvage synthesis. Unlike de novo synthesis, remedial synthesis is simpler and consumes less energy. Two enzymes with different specificities participate in the salvage synthesis of purine nucleotides. Adenine phosphoribosyltransferase catalyzes the synthesis of AMP from PRPP and adenine. The remedial synthesis of purine nucleoside in human body can only be catalyzed by adenosine kinase to change adenine nucleoside into adenine nucleotide. Remedial synthesis of purine nucleotides is a secondary pathway. On the one hand, its physiological significance lies in saving energy and reducing the consumption of amino acids. On the other hand, it has important physiological significance for some tissues that lack the main synthetic pathway, such as human white blood cells and platelets, brain, bone marrow, spleen and so on.