Kaifeng University has civil and architectural engineering college, mechanical and automotive engineering college, electronic and electrical engineering college, materials and chemical engineering college, information engineering college (software vocational and technical college) (public computer teaching and research section, mathematics teaching and research section), finance and economics college, tourism college, art and design college, foreign language college (public foreign language teaching and research section), humanities college, medical department, international education college, innovation and entrepreneurship college, continuing education college, and valve.

Kaifeng University 12 College has two departments, five public teaching and research sections, and more than 50 majors, covering six categories: engineering, management, literature, economics, medicine and art. The department of traditional Chinese medicine has the strongest comprehensive strength (two state-controlled majors, namely stomatology and clinical medicine), and the school with the largest number of students and the oldest qualifications is the School of Finance and Economics (seven majors).

The school has only one undergraduate major, which is jointly organized with Henan University, and awarded the graduation certificate of Henan University, majoring in civil engineering. The school has five majors, three in science and two in liberal arts. Liberal arts majors are tourism management of Tourism College and logistics management of Finance and Economics College respectively. Needless to say, national control majors and undergraduate majors are relatively the best majors.