During the Ming Dynasty, especially at the end of the Ming Dynasty, the commodity economy in the south was developed. The grain-producing areas in China mainly depended on the south, and the north mainly became the political center. The difference of economic degree directly leads to the commercialization of painting and calligraphy, and southern painting and calligraphy can better adapt to economic aesthetics and produce regional schools. In the Ming Dynasty, the artistry of calligraphy was increasingly enhanced, which was related to the emergence of professional calligraphers, who also formed schools with regions as the link.