The history of Mount Sinai Hospital began in 1892, when the young Hebrew Women's Association began to raise funds to "care for the poor and the sick". 1903, decided to use these funds to build a hospital to meet the needs of East Jews in Cleveland. Mount Sinai Hospital opened in East 32nd Street, and later moved to a larger hospital in East 19 16. Although Mount Sinai was originally a Jewish hospital, it quickly became the main health care provider for the urban poor in Cleveland, regardless of race or religion. The hospital is in a leading position in many research and education fields, and is famous for separating conjoined babies for the first time.

The high cost of providing medical services for uninsured patients and Cleveland's highly competitive medical economy led to the closure of 1996 hospital. The legacy of the hospital is preserved in Mount Sinai Medical Foundation, a non-profit funding organization dedicated to research, education and continuing to serve the Jews in Cleveland and the poor urban communities.