After the May 4th Movement broke out, she took an active part in street speeches and appealed to all sectors of society to donate money to support the arrested students, which was blocked by the school. This made her realize that although the educational methods in foreign schools are advanced, they have a strong colonial color, and she came up with the educational thought of taking teachers as a profession and combining the educational methods of foreigners with the patriotic beliefs of her own nation. After graduation, she worked in the Chinese Young Women's Christian Association for two years, and then joined Soochow University and the Education Department of yenching university. After graduation, she came to Shanghai Chinese and Western Girls' Middle School and served as the school principal from 65438 to 0932. At that time, all the school texts, even the history of China, were written and taught by Americans. If she failed in English, she could not graduate. 1936, after she became the principal of Chinese and Western Girls' Middle School, she decided to reform the colonial education mode promoted by the school at that time, and hired several teachers from China to form the school administrative committee, which resisted the control of American consultants to some extent. During the Anti-Japanese War, she supported teachers to educate students in patriotism and organized students to rehearse China plays such as Thunderstorm.

After the outbreak of War of Resistance against Japanese Aggression, Xue supported progressive teachers to publicize anti-Japanese, taught students to sing revolutionary songs and organized students to perform revolutionary dramas. When the Japanese army forcibly used the school as a nursing home for the wounded, Xue ignored the safety and made representations to the Japanese headquarters six times. During the Japanese occupation of Shanghai, Wang Puppet Education Advisory Committee was rejected, Japanese classes were not taught in the school, and Japanese women's softball teams were refused to play in the school. After Japan surrendered, Xue led teachers and students to clean up the devastated campus. In 29 and 37, Xue went to the United States twice to study for master's and doctor's degrees in education. 1937 In the late autumn, while studying for a doctorate in the United States, she underwent breast cancer surgery. Before admission, she left her last words: "If the operation is not successful, I hope to take my heart out and burn it to ashes and take it back to my motherland." From 65438 to 0949, Xue resolutely gave up his forthcoming doctorate, declined the advice of his tutor, and left for China to participate in the construction of new China. After several twists and turns, Xue returned to the motherland in the spring of 1950 and continued to serve as the principal of the girls' middle school. In order to realize the promise of "establishing a career", Xue devoted himself to running a school, constantly explored the laws of women's education, and created and accumulated rich experience in women's education. 1979 at the invitation of overseas alumni, he visited the United States, Hong Kong and other places to publicize the construction and educational development of the motherland and encourage them to serve the motherland and their alma mater in various ways. 199 1 winter, Xue personally formulated the goals and tasks of women's education: "Everyone, especially us women, must have a strong will, a broad-minded spirit of seeking advice, a far-sighted vision, a clear distinction between right and wrong, a sense of responsibility and influence on the family and society, and contribute wisdom to the prosperity of the motherland and the happiness of the people." 1984, Xue was hired as honorary president of No.3 Middle School, and joined China in September of the following year.