At the age of six, her family moved to Athens. Because the apartment is adjacent to the open-air cinema, she can enjoy free movies through the bedroom window. At the age of eight, she was fascinated by the piano and others watched open-air movies. With her eyes fixed on the screen, she improvised relevant notes on the piano keyboard with her fingers. He received fifteen years of formal education in Hellenikon Odion in Athens (the school named Odeon has trained many outstanding artists), and then entered the University of Athens to study history and archaeology. 1967 to 1974, she is studying in Paris. She joined exile clubs, focused on ethnomusicology, met the jazz age in Paris, and occasionally wrote commercial songs. Then she returned to Athens, went to a radio station and set up a national music laboratory. 1979 was regarded as a turning point in her fate, and she began her career as a film composer. The collaborator is the Greek poet and director of the new film genre, Cisto Fro Chilstofis. 1982, eleni karaindrou won the original music award at the Thessaloniki Film Festival for the former film Rosa, and the winner was Theo Angelopoulos (An Zhe), the chairman of the jury. Their cooperation began, and the next nine years were fruitful. In 1980s, An Shi wrote his wandering trilogy (also called Making Silence). After the first trip to Cyprus, Anshi praised Eleni as the best partner with classical music strength. Eleni not only created film music, but also dabbled in Greek avant-garde drama. Her second husband is a drama director. So far, Eleni has composed music for 35 plays.

199 1 year, Calandro and Manfred Aicher, the organizer of contemporary music collection company, jointly released her first ECM album, which included Ann's wandering trilogy (voyage to Cythera, beekeepers, scenery in the fog), thus bringing a wider influence to her music. So far, she has labeled four movie soundtrack albums ECM. These works are not the soundtrack of the film, but increase the length and significance of the works on the basis of originality, which shows that she does not regard her works as a detail of the film.