Cocaine, also known as cocaine and benzyl germ alkali, is mostly white crystals, odorless, bitter and numb. Used as a local anesthetic in medicine, cocaine on the market is mostly extracted directly from coca leaves, which is generally impure. It mainly contains benzoyl methyl germ alkali, germ alkali, benzoyl germ alkali, cinnamoyl cocaine, N- formaldehyde cocaine and 6- hydroxy cocaine.

Cocaine ester bond is unstable, and boiling in alkaline, strong acid or aqueous solution can quickly hydrolyze and break the ester group. The main metabolites are benzoyl chloride, accounting for 29%-54% of the total, and methyl acetate, accounting for 26%-60%, as well as norcocaine, ethylphthalein Ai Kang, m-hydroxy cocaine, p-hydroxy cocaine, 3- hydroxy -4- methoxy cocaine and 4- hydroxy -3- methoxy cocaine.

Detection method of cocaine:

The detection methods of cocaine mainly include high performance liquid chromatography, liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, solvent microextraction-on-line dissolution-field amplification sampling-capillary electrophoresis-ultraviolet detection and direct real-time ionization time-of-flight mass spectrometry. Chemical chromogenic method and TLC detection method are simple to operate, but the sample consumption is large and the detection sensitivity and precision are not high.

Instrumental analysis method has high sensitivity and accuracy, but it needs expensive instruments, equipment and specially trained technicians, so it can't realize on-site real-time detection. Immunoassay is simple, efficient, sensitive and suitable for large-scale detection. However, in order to adopt this method, the whole antigen of cocaine with antigenic activity must be obtained, and substances with molecular weight lower than 1000 are not allowed.

The above contents refer to Baidu Encyclopedia-Cocaine.