20 18 licensed pharmacist's "Pharmaceutical Professional Knowledge I" simulation test questions and answers (2)
First, the best multiple choice questions
1. In China Pharmacopoeia, the "general detection method" section is
A, Appendix B, Table of Contents C, Index D, Exception E, Text
Correct answer a
Answer analysis
China Pharmacopoeia is composed of examples, text and appendix. Among them, the model is the basic principle of correctly interpreting and using China Pharmacopoeia and verifying its quality. The model stipulates the * * * issues related to the variety, appendix and quality verification of the text, and the relevant provisions are legally binding; This text contains the quality standards of different drugs and preparations; The main contents of the appendix include general principles of preparations, general principles of biological products, general detection methods, bioassay methods, reagents and test strips, solution preparation, atomic weight, etc. Therefore, the part containing "general detection methods" is the appendix.
2. The following are accidental mistakes
A, method error b, instrument error c, reagent error d, operation error e, temperature error
Correct answer e
Answer analysis
According to the source of error, system error can be divided into method error, instrument error, reagent error and operation error. Errors caused by temperature and humidity changes in the laboratory are accidental errors.
3. Determine the acidity of the solution with an acidity meter. If the pH value of the solution is about 4.5, the standard buffer used to calibrate the acidity meter is
A, phosphate standard buffer (pH6.86) B, potassium hydrogen phthalate standard buffer (pH4.00)
C phosphate standard buffer (pH6.86) and borax standard buffer (pH9. 18)
D potassium dihydrogen oxalate standard buffer (pH 1.68) and phosphate standard buffer (pH6.86).
E. potassium hydrogen phthalate standard buffer (pH4.00) and phosphate standard buffer (pH6.86).
Correct answer e
Answer analysis
Before the determination, according to the regulations under each variety, two standard buffers with a pH difference of about 3 pH units were selected, and the pH value of the test solution was between them.
4. Titrate 20.00 ml hydrochloric acid solution (0. 1000 mol/L) with sodium hydroxide titration solution. The pH range of titration jump is
a、3.00~4.00 B、3.00~4.30 C、4.30~9.70 D、8.00~9.70 E、9.70~ 10.00
Correct answer c
Answer analysis
Titration jump is an important basis for selecting indicator. Any indicator whose color change range is all or part of the titration jump range can be used to indicate the end point of titration. The titration jump range is pH4.30-9.70, and phenolphthalein, methyl red and methyl orange can be used as indicators.
5. Which reagent should be added to eliminate the interference of halogen acid when the halogen acid salt of organic alkali is determined by non-aqueous alkali method?
A, ammonium chloride b, mercuric acetate c, silver nitrate d, barium acetate e and potassium iodide.
Correct answer b
Answer analysis
Due to the strong acidity of halogen acid, the titration reaction is incomplete. Therefore, before titrating with perchloric acid titrant, 3-5ml of mercuric acetate test solution is sometimes added to form mercury halide which is difficult to ionize, so as to eliminate the interference of hydrohalic acid on the determination, and then titrate with perchloric acid titrant.
6. When the drug content is determined by ultraviolet spectrophotometry, the absorbance of the test solution at 300nm is 0.638, and the absorption coefficient of the known drug at 300nm is 365,438+09, so the concentration of the test solution is
A, 0.002g/ml B, 0.005g/100ml C, 0.002g/100ml D, 0.005g/ml E, 0.02g/100ml.
Correct answer c
Answer analysis
According to Bill-Lambert law, the formula of solution concentration is: c=A/El, where the thickness of solution layer is usually 1cm, so the solution concentration is 0.002g/ 100ml. It should be noted here that the unit of calculation result is g/ 100ml.
7.HPLC showed that the retention time of a drug was 1 1.52 minutes, the half-peak width was 3.0 mm (paper speed was 5 mm/min), and its theoretical plate number was
a、735 B、265 C、 106 D、2042 E、2402
Correct answer d
Answer analysis
This problem is based on the formula: n=5.54(tR/W h/2 )2.
Topic tr =11.52min; The half-peak width W h/2 needs to be converted into 3.0/5=0.6min, which is consistent with the retention time; Substitute the above formula to get the result.
8. The PH value of urine is usually at
a、2.8-4 B、3.8-5 C、4.8-8 D、5.8-9 E、7.8- 10
Correct answer c
Answer analysis
The daily urine volume of healthy adults is 1 ~ 5l, and the urine pH value is between 4.8 and 8.0. The main components of urine are water, nitrogen-containing compounds (mostly urea) and salts.
9. Check a drug for heavy metals, weigh the sample 1.0g, and check it according to law. Compared with the control solution made of standard lead solution (10μg/ml) 1.0ml under the same conditions, it should not be deeper. The limit of heavy metals is
A, 0.0 1% B, 0. 1% C, 1% d, 10 parts per million, 20 parts per million.
Correct answer d
Answer analysis
Note: 1.0g needs to be converted into 106μg for unit conversion, and the formula: (10μ g/ml) ×106μ g is ten parts per million.
10, China Pharmacopoeia (version 20 10) stipulates that the limit of salicylic acid impurities contained in aspirin is
a、 1.0% B、 10% C、0. 1% D、0.00 1% E、0.0 1%
Correct answer c
Answer analysis
The testing center of this subject is China Pharmacopoeia (20 10 edition), which stipulates that the limit of salicylic acid, a special impurity in aspirin, is 0. 1%.
1 1, China Pharmacopoeia stipulates to check the clarity of phenobarbital ethanol solution, and its purpose is
A, control intermediate B, control by-product C, check its dissolution D, check its solubility E, and control phenobarbital impurities.
Correct answer e
Answer analysis
Clarity of ethanol solution: phenobarbital impurity has low solubility in ethanol solution, while the main component phenobarbital has high solubility. Therefore, phenobarbital impurities can be checked by checking the clarity of ethanol solution. Methods: Take 65438±0.0g, add 5ml ethanol, heat and reflux for 3min, and the solution should be clarified.
China Pharmacopoeia (version 12 and version 20 10) specifies the following methods for determining the content of lidocaine hydrochloride.
A, GC method b, HPLC method c, UV method d, non-aqueous alkali method e, redox method
Correct answer b
Answer analysis
The determination method of lidocaine hydrochloride in China Pharmacopoeia (20 10 edition) is high performance liquid chromatography.
13, with hydrazide group in structure, can react with ammonia-made silver nitrate test solution.
A, isoniazid B, barbiturate C, nifedipine D, acetaminophen E, lidocaine hydrochloride
Correct answer a
Answer analysis
Reaction with ammonia-made silver nitrate test solution: the hydrazide group of isoniazid has reducibility and can react with silver nitrate test solution to reduce Ag+ in silver nitrate to elemental silver.
14, the content determination of alkaloids in hydrochloric acid is generally selected.
A, sodium nitrite titration b, high performance liquid chromatography c, ultraviolet-visible spectrophotometry d, nonaqueous alkali titration e and nuclear magnetic resonance method.
Correct answer d
Answer analysis
Alkaloids are alkaline and weakly alkaline, so China Pharmacopoeia generally uses non-aqueous titration to determine the content of raw materials.
15. the test method of "other steroids" in dexamethasone acetate should be
A, GC method b, NMR method c, HPLC method d, TLC method e and UV method.
Correct answer c
Answer analysis
The related substances in dexamethasone acetate are mainly other steroids with similar structures. China Pharmacopoeia is tested by high performance liquid chromatography, and the chromatographic conditions are the same as those under content determination.
16, the statement about the physical and chemical properties of vitamin B 1 is correct.
A, ultraviolet absorption, optical activity B, fat solubility, sulfur pigment reaction C, water solubility, quaternary ammonium structure D, fat solubility and optical activity
E, water solubility and optical activity
Correct answer c
Answer analysis
Vitamin B 1, also known as thiamine hydrochloride, is a quaternary ammonium compound composed of aminopyrimidine ring and thiazole ring connected by methylene. The quaternary ammonium nitrogen atom on thiazole ring and pyrimidine ring is alkaline, and the medicine is hydrochloride. Vitamin B 1 is soluble in water, slightly soluble in ethanol and insoluble in ether. Vitamin B 1 has ultraviolet absorption, and the maximum absorption wavelength of its hydrochloric acid solution is 246nm.