Yan Wang is clever and studious. He was deeply influenced by his father since childhood and loved natural science. 192 1 was admitted to Zhejiang Lijia Technical School (one of the predecessors of Zhejiang University) and studied in the Department of Applied Chemistry. Since then, Rebecca has forged an indissoluble bond with chemistry. 1927 was admitted to the Department of Industrial Chemistry of Jinling University. 193 1 Graduated with Bachelor of Science. Because of his excellent academic performance over the years, he won the Golden Key Award of the Fittfield Society. After graduation, he was recommended by the school to Peking Union Medical College as a graduate student and later transferred to a researcher. He studied the biochemistry of sex hormones under the guidance of the famous biochemist Hsien Wu. He first measured the effects of androgen on various organs of normal rats and ovariectomized rats with a newly developed Waburg micro-respirator. Under the guidance of famous teachers, Wang You's research talent stood out, published four papers, and won the esteem of Hsien Wu. In August, 1935, Wang You, as a member of the chinese association for physiological sciences delegation, attended the 5th International Physiology Congress 15 with Hsien Wu. This is the first time that Wang You has attended a large-scale international academic conference abroad. He met many international physiological and biochemical masters who have been admired for a long time, such as Pavlov, the discoverer of insulin, F.G. Banting and so on. This made him determined to work hard and hope to become one of the internationally renowned scholars in the future. After the conference, Wang You went to the Institute of Chemistry of the University of Munich, Germany, and became a graduate student under the guidance of Vilander, a famous chemist and Nobel Prize winner.
Under the guidance of Vilander and his assistant E. Dane, Wang You was engaged in the synthesis of unsaturated cholic acid and sterols. An improved method of introducing conjugated dienes into steroid rings was found, and cholesteryl dienone and cholesteryl dienol were synthesized. 1in the winter of 937, Rebecca received the best doctor of science degree from the University of Munich. /kloc-in the autumn of 0/938, I went to the Institute of Chemistry of Royal William Medical College in Heidelberg as a visiting researcher. Under the guidance of R. Kuhn, a famous chemist and Nobel Prize winner, the chemistry of crocin was studied. Tetraacetyl crocin was synthesized. This is the organic compound with the largest molecular weight at that time. Wang You received excellent study style and strict training from famous teachers and academic institutions at home and abroad, and developed a serious and rigorous study style and innovative spirit, which had a far-reaching impact on his future career.
/kloc-0 In the spring of 939, Wang You left Germany for England. I am a visiting researcher in the E.C.Dodds research room of Kautaur Institute of Biochemistry, Sanjie Medical College, London, engaged in the chemical synthesis of estrogen analogues. At that time, Europe was clouded by war, and China was being ravaged by Japanese fascism. With a strong desire to revitalize the scientific cause of the motherland, Yan Wang resolutely gave up the superior scientific research conditions and material life abroad and returned to China in August 1939. He used to be a lecturer and assistant professor at Peking Union Medical College. In addition to giving lectures, he continued to engage in the chemical research of steroid hormones under the guidance of Hsien Wu, including the determination of steroid glycoside excretion in urine of pregnant women, and the research on the effective components and pharmacological effects of traditional Chinese medicine Angelica sinensis. In a study in cooperation with obstetricians and gynecologists, he found that the urine excretion of steroid glucose in pregnant women with twins was particularly high. After the Pearl Harbor incident, the Japanese invaders occupied Union Medical College in June 5438 +0942+10, and all the research equipment, materials, research records and samples were looted by the Japanese invaders. Professors, doctors and students were forced to leave laboratories and medical schools.
Pioneer of antibiotics in China
1in April, 942, Wang You entered Shanghai Kang Bing pharmaceutical factory as the director and director of the research office. This is a small pharmaceutical factory, which mainly produces injections, cough and throat tablets and so on. At that time, Shanghai fell and the audio-visual was blocked. 1944, he accidentally learned that an antibiotic cultivated by mold was found abroad, which aroused his desire for a new subject. He studied microbiology, fermentation and other knowledge. Study hard, determined to explore the road of antibiotic research in China. Wang You became interested in the rotten hair on the surface of moldy oranges. After several years of research and experiments, overcoming various difficulties, an antibacterial substance citrinin was finally isolated. From 65438 to 0947, Wang You's paper Citrinin was published in the American journal Science. China Ta Kung Pao and other newspapers reported that he had successfully studied citrinin. An American news agency also made a report. However, Wang You's talent and research results were not appreciated by the factory owner, and Wang You left Kang Bing Pharmaceutical Factory angrily on August 1947.
From June, 65438 to September, 0947, Wang You borrowed two original pathology and autopsy laboratories from the Preparatory Office of the Institute of Medicine of Academia Sinica, and continued the research on citrinin with two assistants who voluntarily resigned from Kang Bing Pharmaceutical Factory. At that time, he had no salary, and the life of Wang Yan's family was very poor, but he longed for poverty, worked hard and buried himself in research. With the cooperation of the assistant, the research on the chemical and antibacterial effects of citrinin has never been interrupted. Later, with the support of Lin Kesheng and Te Pei Feng, he was hired as a researcher in the preparatory office of the Medical Research Institute. During this period, Wang You published six papers, including Antibiotic Citrinin, Dihydrocitrinin and Structure and Antibacterial Activity of Citrinin and Its Derivatives. After the founding of New China, China Academy of Sciences was established, and Wang You was hired as a researcher at the Institute of Physiology and Biochemistry of China Academy of Sciences. 1at the end of 952, he was transferred to the Institute of Organic Chemistry as a researcher and deputy director. Because the party and government attached great importance to the development of scientific research, he was able to systematically study the structure, synthesis, biological effects, toxicity and pharmacology of citrinin, and finally achieved fruitful results. He has published more than 0 papers 10, such as citrinin and citrinin alcohol. Although citrinin can't be used in clinic because of its toxicity, in the 1940s, under such simple and difficult conditions, Wang You began to study citrinin systematically and became a pioneer in antibiotic research in China. His research achievement won the third prize of the annual science award of China Academy of Sciences 1956. The 1950s was the heyday of antibiotic research. With the development of medical care, it is urgent to vigorously carry out the research on antibiotics. Wang You is an active advocate and organizer. 65438-0952, under the leadership of China Academy of Sciences, Wang You participated in the organization of the first national antibiotic work conference. Later, he participated in the organization of Shanghai Antibiotic Research Working Committee and National Antibiotic Research Working Committee. 1955 hosted an international conference on antibiotics in Beijing. These activities have promoted the research and production of antibiotics in China. At the same time, he and his collaborators began to study the separation, purification, structure and synthetic chemistry of streptomycin and chlortetracycline in 1953. He has published nearly 10 papers on the breeding, fermentation and extraction of streptomycin, the synthesis of L- dihydrosaccharides from L- dihydrosaccharides, and the antibacterial mechanism of chlortetracycline. In 1950s, he and his assistant synthesized several cation exchange resins with excellent performance, which were used to extract streptomycin and alkaline antibiotics from fermentation broth. They boldly put forward the ion exchange resin method to replace the activated carbon separation process used at that time, and went deep into the production site for many times to guide and help solve the production process problems. Yan Wang not only attaches importance to practical application topics in production, but also does not neglect basic theoretical research in disciplines. In the stereochemistry study of streptomycin, he and his colleagues revised the conclusion that the β-glycosidic bond of chain disaccharide proposed by M.L.Walfrom, a famous American carbohydrate expert and determinant of streptomycin structure, and confirmed it as α-glycosidic bond. This achievement was selected into Shanghai 1960 scientific research achievement collection.
One of the pioneers in bioorganic chemistry, China.
After the founding of New China, Wang You's research career entered a golden age because of the country's emphasis on science. Since 1960s, Wang You has successively carried out research on basic substances of life-protein, nucleic acid and polysaccharide, as well as research on organic catalysis, biocatalysis, petroleum fermentation and single cell protein production, simulated enzyme chemistry and biosynthesis. His research activities covered almost all the contents of bioorganic chemistry in this period. These studies have been recorded in the history of organic chemistry development in China with excellent results.
From September 65438 to September 0965, China synthesized crystalline bovine insulin for the first time in the world. It is the first fully synthesized protein with the same properties and biological activities as natural products. The molecular composition and structure of insulin were expounded by British scientist Sanger during the period of 65438-0955. Although scientists all over the world have been exploring the artificial synthesis of insulin since then, due to the complex structure and huge workload of insulin synthesis, it was not until 1958 that the British magazine Nature asserted that "artificial synthesis of insulin may not be realized for a long time." However, in this worldwide scientific competition, Chinese scientists took the lead, and our country got the synthetic crystalline bovine insulin. This remarkable achievement has won high praise from the international scientific community. The total synthesis of crystalline bovine insulin was completed by some scientists from the Institute of Biochemistry, China Academy of Sciences, Shanghai Institute of Organic Chemistry and Peking University. Wang Yinglai, Wang You and Xing are responsible for leading and organizing this research. Wang You also directly participated in the total synthesis of bovine insulin A chain, C 14 labeled bovine insulin and other research projects. Clear and specific requirements are put forward for the synthesis scheme and the identification and analysis standards of products. Wang You and his collaborators have published papers such as Research on Peptides, Total Synthesis of Crystalline Bovine Insulin, Synthesis of Bovine Insulin A Chain and Its Synthesis with Natural B Chain, Synthesis of Bovine Insulin A Chain Labeled with C 14 and Bovine Insulin Labeled with C 14. The success of insulin synthesis has promoted the establishment of polypeptide hormone pharmaceutical industry and the development of biochemical reagent industry in China.
The total synthesis of yeast alanine transferase RNA from 1968 to 198 1 is another achievement in the basic research of natural science in China after the total synthesis of insulin, another brand-new scientific research achievement in the research history of biochemistry and organic chemistry in China, and a dazzling chapter in Rebecca's scientific research career. 1967 In April, Marshal Nie, then director of the State Science and Technology Commission, held a symposium on basic theoretical research in Beijing. Wang You first put nucleic acid chemistry on the agenda as his next goal. This proposal was endorsed by the participating scientists and supported by Marshal Nie. After deliberation and investigation, China Academy of Sciences officially issued the task on 1968, and listed "synthesizing yeast alanine into ribonucleic acid" as a major scientific research project, and organized Shanghai Institute of Biochemistry, Shanghai Institute of Cell, Shanghai Institute of Organic Chemistry, Peking University Institute of Biophysics, Shanghai Chemical Reagent Factory of Chinese Academy of Sciences, and 100 more scientific and technical personnel to engage in this research. Yeast alanine transfer ribonucleic acid has a molecular weight of more than 26,000 daltons, and is a biomacromolecule composed of 76 nucleotides (including 4 ordinary nucleotides and 7 modified nucleotides) connected by phosphodiester bonds. Yan Wang is the deputy head of the cooperation group. Together with Wang Yinglai, the leader of the collaboration group, and Wang Debao, the leader of the collaboration group, he carefully planned this difficult research. After 13 years of efforts, the total synthesis of yeast alanine transfer RNA was finally completed at19811. This is the first artificially synthesized alanine transfer ribonucleic acid in the world, which contains all modified ribonucleotides and has biological activities such as accepting alanine and participating in protein biosynthesis. This research has made our country step up to a new level in the research of basic substances of life and trained a research team engaged in nucleic acid chemistry and nucleic acid biochemistry for the country. It laid a foundation for genetic engineering, industrial production of nucleic acid and research and development of nucleoside anticancer drugs in China. Wang You and his collaborators have published many papers, such as Total Synthesis of Yeast Alanine Trans-RNA, Studies on Nucleic Acid Chemistry, Synthesis of Yeast Alanine Trans-RNA 3 '- Half Molecule (36-76), Synthesis of Natural Macromolecules with Biological Significance, and Synthesis of Polynucleotides. Wang You also gave academic reports at the International Conference on Nucleic Acid Chemistry, the Sino-German Symposium on Nucleic Acid in protein and the Sino-American Symposium on Natural Product Chemistry. Although the work is very busy, his guidance on this work is very specific and meticulous. He proposed and successfully applied carboxyl imidazole to the acylation reaction of ribonucleic acid, which made progress in the study of monomer protection in nucleic acid chemical synthesis. Subsequently, he used 3 1P NMR * * * vibration and computer technology to study the acylation mechanism and reaction kinetics of carboxyl imidazole, and achieved results. He has published papers on the role of metaphosphate in the reaction of activating nucleotides by TPS or DCC in oligonucleotide synthesis, the reaction mechanism between N- benzimidazole and ribonucleotides, and the mechanism of ribonuclease A hydrolyzing nucleic acids by 3 1pnmr method.
At the same time, Wang You also undertook another important scientific research project-the chemical research of trichosanthin. Trichosanthes root is a unique Chinese medicine for inducing labor in China, which has been recorded in Song Dynasty. At the end of 1966, researchers from the Institute of Organic Chemistry began to do this research. 1972, at a scientific research planning meeting of the State Science and Technology Commission, Wang You suggested that the research of Trichosanthes kirilowii be listed as a key topic of the Chinese Academy of Sciences. He believes that this basic theoretical research has important academic significance and clear application prospects. Since 1978, Wang You has participated in and directly guided the determination of the primary structure of trichosanthin, an effective component of trichosanthin, and completed the preliminary determination of the secondary structure and spatial structure with the cooperation unit * * *. This is the first protein completely separated, purified and determined by China chemists and physical chemists. Wang You was warmly welcomed and highly praised by the participating scientists when he delivered a speech at 1985 International Union of Pure and Applied Chemistry (IUPAC) Symposium on Organic Chemistry of Medicinal Natural Products. He has published many papers such as Scientific Evaluation of Trichosanthin-History, Chemistry and Application, and edited the book Trichosanthin. Wang You has also made great achievements in the study of polysaccharide chemistry. The most outstanding achievement is the successful development of a new, efficient and safe plasma substitute (vasodilator)-carboxymethyl sugar starch with Tu et al. This is an original plasma substitute in China, which has the same effect as dextran, a widely used plasma substitute in the world, but it has the advantages of easily available raw materials and simple technology, and has been widely used in clinic. 1979 An article in the British magazine Nature mentioned that many of China's achievements are "copying western patent materials", but this achievement is "original" (groundbreaking). When foreign scholars visited Shanghai Institute of Organic Chemistry, they were still very interested in this project. It is worth mentioning that after the first generation of plasma comes out, it is necessary to test the safety of healthy people. Yan Wang was one of the first applicants to take the exam voluntarily.
In the early 1960s, Wang You proposed to carry out basic research on organic catalysis and biocatalysis. Wang You and Wang engaged in biocatalysis research, and soon achieved results, and revealed the application prospect-petroleum microbial transformation. Wang You is keenly aware of the significance of this research to the national economy, especially to agriculture and animal husbandry, so he lost no time to turn this research into applied basic research, expand the laboratory research results to pilot tests and design trials, and organize and coordinate various application experiments. Wang You is a pioneer in the research of producing single cell protein by petroleum fermentation in China. He has published papers such as Preliminary Report on Production of Branched Nonoleic Acid and Dodecanoic Acid by Microbial Oxidation of Paraffin Oil, Preliminary Report on Production of Hydroxy Acid by Microbial Oxidation of Paraffin Oil, and Production of Branched Fatty Acids by Mycobacteria in Paraffin Oil Fermentation Broth. Wang You also published some papers such as "Some Problems of Petroleum Protein as a New Feed" and "Further Study on China Normal-alkane Yeast as Food" at the 19865433 Vienna General Assembly of the United Nations Industrial Development Organization and the 1 Paris International Conference on Single Cell Protein. The study of producing single cell protein as feed by petroleum fermentation passed the national appraisal. In the late 1950s, Wang You was responsible for and completed the analysis of two reactive dyes urgently needed by the country as scheduled. In the 1960s, he was responsible for the military task of analyzing the film bases and infectious substances in high-sensitivity high-altitude reconnaissance films. Starting from 1985, Wang You led the research on the biosynthesis of the effective components of the antimalarial drug Kobresin. Published papers include "Two-dimensional NMR Study on Chrysotile", "Biosynthesis of Chrysotile" and "Artemisinic Acid, Key Intermediates of Chrysotile B Biosynthesis". 65438-0986, based on the research of chemistry and nucleic acid chemistry in protein, Wang You organized human resources to carry out simulated acid chemistry research, and published five papers, including Peptide I. C Terminal Peptide and Peptide Ribonuclease A with Nucleic Acid Synthesis Activity and Their Hydrolytic Synthesis Activity. Wang You's academic achievements enjoy a high reputation in academic circles at home and abroad and are commended by the state. Two of them won the first prize of national natural science: artificial total synthesis of bovine insulin (1July 1982) and artificial total synthesis of yeast alanine transfer ribonucleic acid (1August 1988); One won the second prize of National Natural Science: Trichosanthin Chemistry (1August, 988); One won the third prize of natural science of China Academy of Sciences (19561); And many national science conference awards (1978).
In his research career of more than half a century, Wang You has always been at the forefront of the development of organic chemistry, and has made many achievements in the research on the chemistry of basic substances of life and other natural products, making contributions to the development of organic chemistry in China.
Make greater contribution to the development of organic chemistry in China.
Wang You is an outstanding representative of organic chemists in China. This is not only because he has made great achievements in organic chemistry research, but also because he has trained and organized a well-trained and effective team for the country for decades, which can undertake major scientific research projects and build organic chemistry research bases. Since Rebecca was transferred to Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences from 65438 to 0952, he has successively served as deputy director, acting director, director and honorary director. He devoted all his energy to the growth and development of the Institute of Organic Chemistry. The lifelong pursuit is to revitalize China's organic chemistry and push it to the advanced level in the world.
According to the actual situation of organic chemistry research in China and the law of organic chemistry development, Wang You put forward the system of organic chemistry research institute and the policy of "two courses, two courses and two assistants". The second course is organic synthetic chemistry and physical organic chemistry. The second weft is natural organic chemistry and elemental metal organic chemistry; The second assistance is to cooperate with the research work of the whole institute and establish analytical chemistry laboratory and biochemical laboratory. With the rapid development of computer technology, in 1973, Wang You proposed to establish a computer chemistry laboratory in time. Organic chemistry has a strong research power in organic synthesis, but there was no special laboratory engaged in the research of physical organic chemistry before the 1970s. 1973, Rebecca proposed to establish a physical organic chemistry laboratory. Please welcome Jiang who is good at physical and organic chemistry. As the director of the laboratory, he organized the research on theoretical problems of organic chemistry. The proportion of basic research is guaranteed by the institution. During his decades as the director of the Institute of Organic Chemistry, Wang You led the staff of the Institute to actively undertake the applied research projects assigned by the state, and at the same time encouraged scientific researchers to be enterprising, make efforts to carry out basic research and explore new disciplines and fields. Yan Wang presided over and led nearly 10 basic research projects, and personally participated in and organized many major application projects, even research projects. Over the past 40 years, the Institute of Organic Chemistry has made great achievements in both basic research and applied research. * * * Published more than 2,600 research papers and obtained 300 research results. These achievements are proof of the stable and healthy development of the college.
Wang You attaches great importance to the cultivation of talents. As the director in charge of business, he is well aware of the importance of building a strong soldier with real talent and courage to explore for the scientific cause. Since the 1950s, Yan Wang personally presided over the formulation of the business study plan for the scientific researchers in our hospital, which enabled them to quickly master the latest knowledge of basic theory of organic chemistry, separation technology, stereochemistry, spectroscopy and so on. He has taught many times for professional foreign language literature reading tutorial classes, organic chemistry micro-operation short courses, organic chemistry experimental classes and German training classes. Graduate students are enrolled from 1955. By 1965, Rebecca * * * has trained 7 graduate students and a group of on-the-job scientific and technical personnel. Wang You pays attention to cultivating students' independent working ability, solid basic knowledge and serious and rigorous academic style. After 1978, Wang You was appointed as a member of the Academic Degrees Committee of the State Council and an academician of China Academy of Sciences, and was personally responsible for guiding the postgraduate training of the Institute. In the late 1980s, regardless of his advanced age, he went to Xinjiang twice and Yunnan once to guide the scientific undertakings in remote areas, and gave detailed guidance on the research direction, personnel training and instrument maintenance of relevant local scientific research institutes to help them solve some research problems. For example, Xinjiang Institute of Chemistry is weak in natural organic chemistry. With the support of Wang You, the Institute of Organic Chemistry sent Zhou Weishan and Lin Guoqiang to Xinjiang for short-term job training. Rebecca also personally trained a Uighur female advanced student, and also trained graduate students for Xinjiang Institute of Chemistry. Protein's structural analysis is relatively weak in China. 1980, Yan Wang invited two German structural chemists, B. Vidtman-Libotte and A. Henschen-Erdtman, from West protein to the Institute of Organic Chemistry to hold a seminar on micro-sequencing in protein. After that, the institute held another study class and extended this new technology to many units in China, which contributed to improving the detection level in this field in China and was well received.
Since the reform and opening up, Wang You has actively created conditions for the business backbone of the Institute to go abroad for further study and study. According to the specialty setting direction and discipline development trend of the institute, he sent researchers abroad to study advanced science and technology in a planned and focused way and returned to serve the motherland.
Entrusted by chinese chemical society, Wang You was the editor-in-chief of Journal of Chemistry for 24 years. Thanks to his unremitting efforts, the magazine has developed from quarterly to bimonthly, and then to monthly, and its length has also been increasing. The English version of the Journal of Chemistry was founded on 1983, so that the international academic community can keep abreast of the research progress of its domestic counterparts.
Wang You has done a lot of useful work for the exchange and friendship between China and international academic circles. He is one of the hosts of Beijing International Antibiotics Conference (1955), China protein and Nucleic Acid Seminar (1979) and China-US Natural Products Chemistry Conference (1980). Organized and presided over 1985 International Union of Pure and Applied Chemistry (IUPAC) Shanghai Seminar on Organic Chemistry of Medicinal Natural Products, attended by more than 400 scientists from 33 countries and regions on five continents. His academic level and organizational work were highly praised by the participating scientists. Since 1950s, he has visited Belgium, Netherlands, Britain, Austria, Czech Republic, Democratic Germany, Federal Republic of Germany, Cuba, Australia, Romania, France, Switzerland, Sweden, the United States, the Soviet Union, Japan, Hong Kong and other countries and regions, and attended international academic conferences. We have established and maintained friendly exchanges and close ties with many internationally renowned scientists. Wang You's academic achievements have been praised by foreign colleagues. He was hired as the consultant editor of Tetrahedron and Tetrahedron Communication (1982- present), Tetrahedron Computer Chemistry and Tetrahedron Asymmetric Synthesis (1989- present) and Nucleic Acid Research (1982- present). In 1984, he was included in the seventh edition of Marquez's Who's Who in the United States. In March of 1984, he was elected as a foreign academician of the French Academy of Sciences.1987165438+10, Munich University held a grand ceremony to get a doctorate for 50 years. This is a great honor. 1988 was elected as a member of the Communication Department of Bavarian Academy of Sciences in Germany. 1990, when he was 80 years old, Tetrahedron, Volume 46, No.9, was a special issue dedicated to Wang Yan's 80th birthday, and collected academic papers written by famous organic chemists at home and abroad. Among them are famous organic chemists from the United States, France, Britain, Germany, Japan, Switzerland, Hong Kong and other places, which is an honor given to Yan Wang's academic achievements by international academic circles.
Seek and be strict with yourself.
Wang You has the spirit of devoting himself to the scientific cause of the motherland. For many years, he always gets up early and goes to bed late, and works late into the night every day. Scientific research is his whole life. He has published more than 65,438+000 papers and won nearly 65,438+00 awards. For half a century, he has always stood at the forefront of discipline development and bravely met challenging problems. He studied steroids in the 1930s, antibiotics in the 40s, and then synthesized insulin and RNA. His pursuit of "infinite knowledge" never stopped. How many times has he discussed or even argued some scientific propositions with his peers or students? He opposed the idea of stagnation and was brave in making progress. Therefore, when synthesizing insulin, he thought about deepening the achievements of protein's chemistry, and at the same time carried out the research on nucleic acid chemistry, another important basic substance of life. After the brainstorming of domestic scientists, the topic of "artificial synthesis of yeast alanine transfer ribonucleic acid" was formed. 13 years later, the task of nucleic acid synthesis was completed through the painstaking research of hundreds of people before and after. While celebrating this achievement, Wang You published an article entitled "Boundless Knowledge, Merits of Generations" (Hongqi No.4, 1982). He warned his colleagues, assistants and students that "learning is endless" and they should not be satisfied with what they have achieved. It takes generations of unremitting efforts to uncover the mysteries of natural science. Wang Yan practiced. Although he was 70 years old at that time, he was still full of enthusiasm and continued to conquer the new fortress of science. 1985 and 1986, he organized manpower to carry out two important disciplines that are still blank and have not been systematically studied in China. Many papers have been published in biosynthesis and simulated enzyme chemistry, and gratifying results have been achieved.
Wang You's spirit of seeking novelty and refinement in his research work is another feature of his academic attitude. He boldly and actively adopted new methods and technologies. When he was in charge of the Institute of Organic Chemistry, he attached great importance to the configuration and updating of large-scale instruments and equipment. China's first infrared spectrometer and nuclear magnetic resonance oscillator used in organic chemistry research were first established in this institute. He always actively applies new technologies in his research work. When he was engaged in antibiotic research, he took the lead in adopting advanced technologies at that time, such as ion exchange, chromatography and electrophoresis. In the research of insulin, nucleic acid and mimic enzyme, he applied advanced technologies such as isotope technology, nuclear magnetic resonance and computer to detection, dynamic tracking and mechanism research in time. He determined the structure of Trichosanthes kirilowii by computer fitting method for the first time, and achieved gratifying results. All the research topics that Wang You is directly responsible for, from route design, synthesis method, analytical means, data processing to writing papers, are personally guided, strictly controlled and meticulous. The total synthesis of insulin has been evaluated twice. At the first appraisal meeting concluded in 1965, most experts attending the meeting expressed satisfaction with the research results. However, as one of the main persons in charge of this achievement, Yan Wang took the lead in attacking, pointing out that although the synthesis of insulin was basically completed, the data was not enough, and some necessary data needed to be supplemented for further identification. His rigorous and realistic style of study was appreciated by the participants, which made the second appraisal meeting held a few months later a complete success.
Wang You loves young people and supports them after school. 1984 voluntarily resigned from the leadership position of research institute and laboratory, and let young and middle-aged chemists shoulder the heavy burden. He said: "Young and middle-aged people are quick-thinking and full of energy. It is bound to be conducive to the creation and development of science and technology to renew their old age with young and middle-aged people. Of course, old scientific and technological workers have more mature experience and broader knowledge, knowledge and ideas, but the natural law of physical decline and dullness is irresistible. Old scientists should actively, consciously and realistically train young successors. " His actions set an example for the old comrades of the Institute and promoted the pace of institutional reform of the Institute.
Wang You's encyclopedic knowledge. He is proficient in English and German, can read French, Russian and Japanese documents, and is familiar with allusions and anecdotes in the history of science at home and abroad. He often uses these stories to teach his assistants and students and point out the way to success. Wang You loves to write poems in order to tell stories and express his feelings.
Wang You is honest, noble in character, consistent in words and deeds, practical and willing to work, tolerant and self-disciplined, and never seeks personal gain. During the "Cultural Revolution", Wang You was framed, and in adversity, he still adhered to his principles, refused to admit the charges against him, and did not tell a lie. He silently endured the great trauma left by the "Cultural Revolution" and did not express his grievances. After he was re-appointed as the director of Shanghai Institute of Organic Chemistry, he was as generous as ever and never cared about personal grievances. After the downfall of the Gang of Four, the organization began to solve the housing problems of some high-tech researchers and got ideal houses. The organization plans to let Rebecca move in. Wang Yan thanked him politely and said, "My house is all right. I am too old to live in it for a long time. " He gave up a better house to another Gao Yan.
Wang You's self-denial and dedication to public service clearly distinguish between public and private. He has frequent foreign affairs activities, and has academic exchanges and meetings every year. All private cars and photocopying materials are paid out of their own pockets, and all expenses such as treating guests and giving gifts or mailing calendars in the name of individuals in foreign affairs activities are never reimbursed from public funds. On the contrary, when visiting or attending international conferences abroad, he saves food and transportation expenses as much as possible, including the money saved by giving academic lectures abroad, buying typewriters, slide projectors, and reagents urgently needed for research. Since the implementation of the bonus system, he has not received anything, whether it is the paper payment, research achievement bonus, monthly award, year-end award, etc. Even the editor-in-chief fee and peer review fee of Journal of Chemistry are paid to the editorial department. He believes that all his achievements depend on everyone's efforts and the credit belongs to everyone. In recent years, Wang You has recommended many people to go abroad, which has created many conditions for the business backbone of the institute to go abroad for further study. But he never wrote a letter of recommendation to his daughter who studied chemistry, and did not provide her with the opportunity to go abroad. When someone asked him why he didn't arrange for his daughter to go abroad, he replied, "Studying abroad depends on my own efforts. If I contact her first, how can I implement the national policy in my office! " Wang You is such an excellent scholar who is strict with himself and does not seek personal gain.
Wang You 196 1 Join the China * * * Production Party. He loves the Party, maintains its prestige and supports socialism. He has a strong party spirit and always sets strict demands on himself with party member's high standards. 1959 to 1987, elected as deputies to the second, third, fifth and sixth national people's congresses. 1986, Wang You was rated as an excellent party member. Everything he said and did strictly fulfilled the oath he made when he joined the party. "I am determined to become a glorious party member, a faithful believer and practitioner of Marxism–Leninism, and a pioneer of the party's revolutionary cause."