In order to explore anti-tumor, anti-drug resistant bacteria and anti-virus drugs, suitable natural compounds are actively selected for total synthesis research to obtain available lead compounds. In addition to innovative mycin, the synthesis of penicillin derivatives, the main anti-tumor antibiotic G-0069, the ring-opening compound of dienyl anti-tumor antibiotic C- 1027 chromophore, and the nucleoside antibiotic Saindomycin was also completed. In order to explore drugs against human immunodeficiency virus (H Ⅳ), the total synthesis range of natural compounds was expanded beyond microbial products. In view of the antiviral effect of some Chinese herbal medicine components, the total synthesis of hypericin, ethyl hypericin, neobaicalin and its derivatives was completed through experimental exploration. It is found that hypericin and ethyl hypericin have the activity of inhibiting H ⅳ reverse transcriptase of human immunodeficiency virus. Ethyl hypericin is a new compound, which is more fat-soluble than the corresponding methyl homologues, and has stronger activity of inhibiting H ⅳ reverse transcriptase than natural hypericin. The results showed that some new baicalin and its derivatives without benzyl protection group had no activity against H Ⅳ and adult leukemia virus.
Attach importance to discipline development and care about youth education.
Professor Zhang Zhiping has published academic papers 10 1 at home and abroad, edited Microbial Pharmacology (Chemical Industry Press, 2003) and Microbial Pharmacy (Chemical Industry Press, 2002), and participated in the compilation of China Encyclopedia of Medicine-Pharmacology and Pharmacology (edited by Huang Liang) and Encyclopedia of Chemical Industry (Chen
Professor Zhang Zhiping is knowledgeable and accomplished. He can always keep a close eye on the development of new drug research and medical biotechnology at home and abroad, and is often invited to write a review of the research progress of antibiotics and antibacterial drugs, which has a wide readership and is very popular.