Risk of arteriosclerosis
Atherosclerosis is a manifestation of vascular aging and is closely related to the blood supply function of the heart. It's like a mine buried all over the body. If arteriosclerosis occurs in many parts of the body at the same time, it is very dangerous.
However, arteriosclerosis is a chronic disease, just like a frog cooked in warm water, which lurks in the body for many years, but suddenly leads to myocardial infarction, stroke and even sudden death, so we must pay attention to it.
In traditional medicine, the risk factors leading to arteriosclerosis, such as obesity, smoking and drinking, cannot explain why the number of women and young people suffering from arteriosclerosis is increasing year by year.
Looking for the cause of arteriosclerosis? Recently, a study on arteriosclerosis was published in the European Heart Journal, a top magazine in the cardiovascular field. Researchers from King's College London selected 6 17 middle-aged British women and sequenced their intestinal microbes.
And after a detailed data survey of all aspects of their lives, such as diet, medication, disease, exercise and so on. , researchers look for the factors of pulse wave velocity (PWV) caused by human body; Pulse wave velocity is an index used to evaluate the degree of arteriosclerosis. The faster the wave velocity, the worse the elasticity and the higher the hardness of the artery.
The lower the diversity of intestinal microorganisms, the higher the degree of arteriosclerosis.
After standardizing the error values of the subjects' age, body mass index, average arterial pressure and family history, the researchers focused on the risk factors of cardiovascular diseases such as obesity and diabetes, and found that intestinal flora imbalance would increase the incidence of heart failure and myocardial infarction, while supplementing Lactobacillus plantarum and Lactobacillus rhamnosus could reduce the area of myocardial necrosis, improve left ventricular function and avoid heart failure after myocardial infarction.
In addition, the latest research also pointed out that traditional cardiovascular risk factors were not found in some people with atherosclerotic plaques, but compared with healthy people, the concentration of trimethylamine oxide (TMAO), an intestinal metabolite, was higher. TMAO was only affected by intestinal microbial composition, and disease or diet did not cause TMAO differences.
TMAO can inhibit the degradation of cholesterol, easily make cholesterol accumulate on the blood vessel wall, gradually form atherosclerotic plaque, and increase the hardness and thickness of the blood vessel wall. However, the scientific literature of 20 15 points out that when mice are fed with foods that produce less TMAO, even if they are fed with a high-fat diet every day, atherosclerotic plaques will not appear, which greatly reduces the risk of arteriosclerosis.
Therefore, the research team found that the diversity of intestinal microorganisms, such as Lactococcus, Renaceae, Clostridium and Corynebacterium aerogenes, was positively correlated with the pulse wave velocity, which also confirmed that the lower the diversity of intestinal microorganisms, the higher the degree of arterial stiffness in women.
Because it will affect cholesterol metabolism. Finally, the research team found that the influence index of intestinal microorganisms on arteriosclerosis was 8.3%, while the influence index of traditional risk factor insulin impedance plus visceral fat was 1.8%, the former was more than 7 times that of the latter.
Intestinal microorganisms are the result of independent influence on arteriosclerosis and cardiovascular diseases, which also explains why women and young people with low obesity and smoking rates still have arteriosclerosis without insulin resistance and visceral fat problems. However, this study is only aimed at women, so we will compare the data of men and other ethnic groups in the future to achieve personalized and precise medical care!