Methanol and acetonitrile are common organic solvents, but their elution abilities are slightly different. Generally speaking, acetonitrile has a strong elution ability. This is because acetonitrile contains two polar carbon-nitrogen bonds, which makes it have high solubility and good solubility. However, methanol contains only one polar carbon-oxygen bond, which is slightly weaker than acetonitrile. Acetonitrile is more suitable as an eluent in some cases because of its large molecular structure and low impurity content.