In the 1980s, the development of science and technology in China was backward, and there was no related discipline theory of forensic identification, advanced experimental equipment and English literature. For medical researchers at that time, many experiments in books were actually impossible to operate. Nowadays, it is hard for researchers to imagine the embarrassing situation of the scientific community in China at that time, but the poor scientific research conditions did not stop Li Shengbin from advancing. His thirst for knowledge was almost obsessive, he overcame many difficulties and began the arduous course of DNA research. After returning from Sun Yat-sen University, under the guidance of Professor Liu Mingjun, a famous forensic scientist in China, Li Shengbin finished his first paper, Polymorphism of DNA. In this paper, he proposed that the essence of human DNA polymorphism is that the nucleotide sequence in chromosome DNA has changed for various reasons during the evolution, that is, the difference between individual DNA fragments and DNA sequences is lifelong. Theoretically, except identical twins, the genetic markers of 5 billion people all over the world are different, but their blood relatives have the same parts. In this article, he also discussed the research progress, application prospect and urgent need of standardization of DNA. He believes that DNA polymorphism and analysis technology show great vitality in biological evidence identification and will bring great changes to forensic science. This paper opened the prelude of Li Shengbin's forensic DNA research, and showed him another promising village, when he was only 27 years old.