According to relevant data, the design principles of ph-sensitive targeted preparations are as follows. Based on the characteristic that the pH value of tumor interstitial fluid is obviously lower than that of surrounding normal tissues, a pH-sensitive liposome was designed. This liposome can release drugs in a low pH range. Generally, pH-sensitive lipids (such as DPPC and phosphatidylcholine) are used as lipid membranes. The principle is that when the pH value decreases, the carboxyl groups of fatty acids can be protonated to form a hexagonal amorphous layer structure, thus accelerating the release of drugs through membrane fusion.