Current location - Education and Training Encyclopedia - Graduation thesis - These hormone values before in vitro transplantation-have you reached the standard?
These hormone values before in vitro transplantation-have you reached the standard?
The process of IVF is like "upgrading". After a series of processes such as early consultation, ovulation induction and egg retrieval, if the embryo transfer is successful, it also means that it will be possible to "graduate" smoothly and completely realize the desire to have children.

For the sake of good imagination, let's stop here.

You know, transplantation is one of the most important processes in IVF treatment. Embryos are too precious to be transplanted casually. Before and during effective transplantation, it is necessary to fully regulate the body and monitor the hormone changes of expectant mothers at any time to ensure the smooth implantation and development of embryos after transplantation.

So, what indicators do we usually use to judge whether expectant mothers can transplant?

First of all, before transplantation, we often have to adjust the hormone level of expectant mothers by injection and other means. Until all indicators are within the normal range, transplantation can be carried out.

We judge by the following indicators: Generally speaking, the most important thing is ovarian hormone, which is divided into estrogen and progesterone.

Estrogen is mainly produced by the ovaries of school-age women. In the normal menstrual cycle of women, the change curve of estrogen level is as follows:

Estradiol level was low at the early stage of follicular phase, and then gradually increased, reaching a peak before ovulation, gradually decreasing to a low point after ovulation, reaching a second peak at 7-8 days after ovulation, but lower than the first peak, and then rapidly decreasing to the lowest level.

Medical results show that estradiol should reach luteal phase before embryo transfer.

Progesterone can thicken endometrium, proliferate blood vessels and glands, and make full preparations for placenta implantation. At the same time, progesterone can also promote the development of mammary glands and prepare for lactation.

The average progesterone value of normal pregnant women is 80.3nmol/L, and the serum progesterone level before transplantation should reach the luteal phase level.

If it is lower than the physiological value, the corpus luteum function is insufficient, and exogenous drugs need to be supplemented to maintain early pregnancy.

Let's look at the reference range of normal progesterone:

The thickness of endometrium is an important index for embryo transfer. Too thick or too thin is not suitable for transplantation.

Usually, when the thickness of endometrium is about 8- 12mm, it is beneficial to the implantation and development of fertilized eggs, and then transplantation can be carried out in an ideal state.

At the same time, we should also pay attention to the health of the uterus. If there is intrauterine adhesion, we need to perform surgical separation treatment as appropriate. It is necessary to confirm the size and location of hysteromyoma, observe whether it will affect embryo development, and then decide whether to have surgery before transplantation.

The process of ovulation induction in the early stage of IVF will change the hormone level in women. For expectant mothers who are not suitable for transplantation, it is usually recommended to freeze the embryos first, wait for conditioning (the specific conditioning time is recommended to follow the doctor's advice), then thaw the recovered embryos, and then transfer the embryos, which can also improve the embryo implantation rate to a certain extent.