The study included 45 women with atypical squamous cells of unknown significance, but high-risk human papillomavirus was negative. The researchers followed him for 2 years and analyzed the cytological regression. The results showed that the cumulative regression rate of atypical squamous cells was 55.6% in the first 6 months, 84.4% in 1 year and 95.6% in 2 years. Cytological regression was not related to the patient's age, menopausal status and baseline HPV load. However, compared with women who have never had cervical injury, the proportion of cytology accumulation and regression in 1 year is significantly lower in women with previous cervical injury (P=0.02), and even lower in women with high intraepithelial neoplasia (P=0.008).