2 English reference Jinshuibao Capsule
3 Overview Jinshuibao Capsule is a Chinese patent medicine, and the prescription and capsule developed. This medicine was developed by Jiangxi National Pharmaceutical Factory.
3. 1 constitutes fermented Cordyceps powder.
3.2 Functions of tonifying kidney and protecting lung, hiding secrets and benefiting qi.
3.3 Indications: chronic bronchitis, hyperlipidemia, sexual dysfunction such as impotence, premature ejaculation, hypofunction, irregular menstruation, women's backache and abdominal pain, leucorrhea, soreness of waist and knees, fatigue and chills, tinnitus and insomnia, loose teeth, etc., which belong to deficiency of both lung and kidney and mental deficiency.
3.4 Usage: Take orally, three capsules 1 time, three times a day 1 time, after meals.
3.5 Clinical Research Through clinical treatment, 656 patients with hyperlipidemia, chronic bronchial and sexual dysfunction were observed, including: 358 patients with hyperlipidemia, the total effective rate of lowering cholesterol was 68.6%, the total effective rate of lowering triglyceride was 57.4%, and the total effective rate of raising high-density lipoprotein was 76.2%; 109 chronic bronchitis with deficiency of both lung and kidney, deficiency of both lung and yin, deficiency of both spleen and kidney, and deficiency of kidney yang, with a total effective rate of 84.4%; Sexual dysfunction 189 cases, the total effective rate is over 50%. Pharmacological studies show that the drug has the following effects: (1) reducing blood lipid and preventing arteriosclerosis; (2) Increase blood supply to myocardium and brain, lower blood pressure and inhibit platelet aggregation; (3) Anti-inflammatory, antitussive, expectorant, antiasthmatic and sedative effects; (4) gonadotropin. The toxicity study showed that the mice did not die when the drug was injected subcutaneously and orally at the maximum concentration and allowable volume. Mutagenesis test and Ames test were negative for teratogenic fetus test, and the internal organs and bones of mice developed normally without abnormal lesions.
4 Pharmacopoeia Standard of Jinshuibao Capsules 4. 1 Name Jinshuibao Capsules
Jinshuibao capsule
4.2 Prescription fermented Cordyceps powder (Cs4)330g.
4.3 Methods Fermented Cordyceps powder (Cs4) was crushed into fine powder and encapsulated, and made into 1000 capsules.
4.4 Properties This product is a hard capsule, and its contents are yellowish brown to light brown powder; It smells fragrant and tastes slightly bitter.
4.5 Identification (1) Take the continuous filtrate 15ml under 【 Content Determination 】, evaporate it to dryness, and dissolve the residue with 5ml diluted ethanol as the test solution. In addition, adenine reference substance, adenosine reference substance and uridine reference substance were added with dilute ethanol to prepare a mixed solution containing 2mg per kloc-0/ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), respectively take 10μl test solution and 1μl reference solution, and spot them on the same silica gel GF254nm thin-layer plate, with 4% sodium carboxymethylcellulose solution as the adhesive and chloroform-isopropanol-ethyl acetate-water-concentrated ammonia water as the solvent. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
(2) Take 65438 0 g of this product, add 65438±00ml of water, heat to boiling, filter, and take the filtrate as the test solution. In addition, leucine reference substance, alanine reference substance and valine reference substance were added together with water to prepare a mixed solution containing 1mg leucine and alanine and 0.5mg valine per 1ml as a reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), on the same silica gel G thin-layer plate, using n-butanol-glacial acetic acid-water (4: 1: 1) as the developing agent, 3μl of the test solution and 2μl of the reference solution were respectively absorbed, unfolded, taken out, dried and sprayed. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
(3) Take mannitol reference substance and add dilute ethanol to make a solution containing 9mg per kloc-0/ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), 3μl of the test solution under [Identification] and 2μl( 1) of the above-mentioned reference solution are respectively spotted on the same silica gel G thin-layer plate, and isopropanol-ethyl acetate-water (9: 6: 2) is used as the developing agent, which is unfolded and taken out. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
4.6 The inspection shall comply with the relevant regulations of capsules (Appendix Ⅰ L of Pharmacopoeia 20 10).
4.7 The content was determined by high performance liquid chromatography (Appendix ⅵ D of China Pharmacopoeia I, 20 10).
4.7. 1 chromatographic conditions and system applicability test, using octadecylsilane bonded silica gel as filler; Using phosphate buffer solution containing 2% tetrahydrofuran [0.066 mol/L potassium dihydrogen phosphate solution -0.066 mol/L disodium hydrogen phosphate solution (2∶3)] as mobile phase; The detection wavelength is 260 nm. The theoretical plate number should be not less than 3000 calculated by adenosine peak.
4.7.2 Preparation of control solution Take about 100mg of adenosine reference substance, accurately weigh it, put it in a 25ml volumetric flask, dissolve it with dilute ethanol and dilute it to scale, shake it evenly, accurately measure 2ml, put it in a 100ml volumetric flask, dilute it to scale with mobile phase, shake it evenly, and get the final product (per1.
4.7.3 Preparation of test solution Take the contents of this product with different loading amounts, mix them evenly, take about 65438±0g, weigh them accurately, put them in a conical flask with a stopper, add 50ml of diluted ethanol accurately, plug them, weigh them, perform ultrasonic treatment (power 250W, frequency 33kHz) 30 for 30min, let them cool, weigh them again, and make up the reduced amount with diluted ethanol.
4.7.4 Determination method Accurately absorb 20μl of control solution and 20μ l of test solution respectively, inject them into a liquid chromatograph, and determine.
The adenosine content (C 10H 13N5O4) of this product should be 0.70 ~1.20 mg. ..
4.8 Indications: tonifying lung and kidney, and storing essence and qi. Can be used for treating lung and kidney deficiency, essence deficiency, chronic cough and asthma, mental fatigue, insomnia and forgetfulness, soreness of waist and knees, irregular menstruation, impotence and premature ejaculation; Chronic bronchitis, chronic renal insufficiency, hyperlipidemia and liver cirrhosis.
4.9 Oral administration and dosage. 3 capsules at a time, 3 times a day; Patients with chronic renal insufficiency, 6 capsules at a time, 3 times a day; Still follow the doctor's advice [1].
4. 10 specification contains 0.33g each.
4. 1 1 storage seal.
4. 12 Edition People's Republic of China (PRC) Pharmacopoeia 20 10 Edition
5. Instructions for Jinshuibao Capsule 5. 1 Drug Type Traditional Chinese Medicine
5.2 Drug Name Jinshuibao Capsule
5.3 Chinese Pinyin of Jinshuibao Capsules
5.4 Component Fermented Cordyceps Powder (Cs4)330
5.5 Character Jinshuibao Capsule is a hard capsule, and its contents are yellowish brown to light brown powder; It smells fragrant and tastes slightly bitter.
5.6 The main function of Jinshuibao Capsule is to tonify lung and kidney, and keep the essence and qi secret. Can be used for treating lung and kidney deficiency, essence deficiency, chronic cough and asthma, mental fatigue, insomnia and amnesia, soreness of waist and knees, irregular menstruation, impotence and premature ejaculation.
5.7 Specification: 0.33g per capsule.
5.8 Usage and dosage of Jinshuibao Capsule is taken orally. Three tablets at a time, three times a day.
5.9 Precautions 1. Avoid indigestible food.
2. Patients with cold and fever should not take it.
3. People suffering from serious chronic diseases such as hypertension, heart disease, liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
Children, pregnant women and lactating women should take it under the guidance of a doctor.
5. After taking the medicine for 4 weeks, the symptoms have not eased, so I have to go to the hospital.
6. Jinshuibao Capsule is forbidden for those who are allergic, and should be used with caution for those who are allergic.
7. Jinshuibao capsules are prohibited from being used when their properties change.
8. Children must use it under the supervision of adults.
9. Please keep Jinshuibao Capsule out of the reach of children.
10. If you are using other drugs, please consult a doctor or pharmacist before using Jinshuibao capsules.
5. 10 drug interaction If used with other drugs, drug interaction may occur. Please consult a doctor or pharmacist for details.
5. 1 1 Remarks