Polio, also known as polio, is an acute infectious disease that seriously threatens children's health. It was popular in many places in China for a while, which caused many families to be heartbroken, but there was no perfect solution at that time. Until now, polio is still a very intractable disease, which is likely to directly affect children's lives and health. Therefore, the vaccine developed by Grandpa Gu can solve or completely treat polio to a great extent, and even inhibit the spread of the disease. Therefore, the research and development of Grandpa Gu's polio virus vaccine has saved hundreds of millions of children in China, which is also his great contribution to the medical cause in China. Through decades of research, the method of isolating and typing poliovirus has been established. Grandpa Gu isolated poliovirus from patients' feces and successfully finalized it, which provided a scientific basis for the formulation of immunization program and formulated the trial production and safety standards of live poliovirus vaccine. It can be said that he has been fighting for the eradication of polio, a terrible acute viral infectious disease of children. He is also one of the pioneers in the tissue culture of oral live vaccine in China, and has made many contributions to the medical cause in China, established the safety standards and verification procedures for polio, and developed polio vaccine, which can solve this serious infectious disease well.