In response to Ms. Zhao's question, we consulted a senior expert professor from Guangdong Institute of Hepatology (winner of excellent papers from the National Symposium on Hepatitis and invited expert from the International Conference on Viral Hepatitis and Hepatology). Professor Zhao Guoqing pointed out that five hepatitis B positives (135), commonly known as three hepatitis B positives, are the results of three hepatitis B surface antigens (1), hepatitis B E antigens (3) and hepatitis B core antibodies (5). Generally speaking, hepatitis B virus is active in replication and relatively contagious in the body. However, the positive rate of hepatitis B five items 135 can not explain the severity of the disease and the degree of liver damage. It is suggested to check liver function, liver B-ultrasound and HBV DNA. According to the results of liver function and B-ultrasound, we can judge whether the condition is serious, and according to the results of HBV-DNA, we can judge the replication and infectivity of hepatitis B virus more accurately, and comprehensively analyze the results of various tests to guide the treatment of hepatitis B. It is recommended that hepatitis B patients who read 135 positive items should actively carry out liver protection and antiviral treatment if they find abnormal liver function or HBV-DNA positive. Special reminder, when transaminase exceeds twice the normal value, it is the best time for hepatitis B antiviral treatment. At this time, if the German anti-HBV blood photooxidation therapy can be actively used for scientific treatment, this therapy is the best technology for antiviral treatment at present. Because this technology has strict requirements for hospitals, there are no more than ten hepatopathy hospitals in China that can fully master this technology, and Guangdong Institute of Hepatology is the only national first-class public hospital with this technology in Guangdong. Recommended reading, domestic authoritative liver disease experts will give you detailed answers.