A large number of small and medium-sized enterprises have always been the most active part of the economy, with the tradition of adopting new technical means and creating new marketing methods. The attitude of small and medium-sized enterprises to e-commerce also determines their own and the future of e-commerce development to a great extent. The main argument of this paper is: 1. In the information age, small and medium-sized enterprises must use electronic commerce means, "either electronic commerce or no business"; 2. With the continuous advancement of informatization, "the era of online merchants has arrived", it is very practical and feasible for small and medium-sized enterprises to exploit the market by using e-commerce. 3. "Dare to invest and fully follow up" should be the basic idea for small and medium-sized enterprises to use e-commerce to open up markets; As long as we insist on honesty and confidence, small and medium-sized enterprises will succeed in e-commerce. The structure of this paper is as follows: The first part explains the necessity of using e-commerce for small and medium-sized enterprises by analyzing the advanced mechanism of applying e-commerce to online marketing and its revolutionary influence on small and medium-sized enterprises' "either e-commerce or no business"; In the second and third parts, by analyzing the development of e-commerce in China's small and medium-sized enterprises, it is clarified that "the era of online merchants has arrived", the strategies of using e-commerce in small and medium-sized enterprises are discussed, and the feasibility of using e-commerce in small and medium-sized enterprises is explained; The fourth part, using the method of case analysis, discusses that the method of small and medium-sized enterprises using e-commerce to open up the market is "dare to invest and follow up with all their strength"; The fifth part analyzes the problems and solutions in the process of developing e-commerce in small and medium-sized enterprises.