Gene and health gene detection Modern medical research has proved that almost all diseases are related to genes except trauma. Just as blood is divided into different blood types, normal genes in the human body are also divided into different genotypes, that is, gene polymorphism. Different genotypes have different sensitivities to environmental factors, and sensitive genotypes will cause diseases under the action of environmental factors. In addition, genetic abnormalities will directly lead to diseases, and the diseases that occur in this case are genetic diseases. It can be said that there are three basic causes of the disease: acquired mutation of (1) gene; (2) Interaction between normal genes and environment; (3) genetic defects. The cause of most diseases can be found in genes. Genes, through their guidance on protein synthesis, determine the efficiency of our absorption of food, elimination of toxins in the body and response to infection. There are more than 4000 kinds of diseases related to heredity in the first category, which are inherited by fathers or mothers through genes. The second kind of diseases are common diseases, such as heart disease, diabetes and various cancers. , is the result of the interaction of various genes and various environmental factors. Gene is the chemical carrier of human genetic information, which determines the similarities and differences between us and our predecessors. When genes "work" normally, our bodies can develop and function normally. If a gene is abnormal, even a very small fragment of the gene is abnormal, it may lead to abnormal development, disease and even death. A healthy body depends on the constant renewal of the body to ensure the normal quantity and quality of protein, and these protein cooperate with each other to ensure the normal execution of various functions of the body. Each protein is the product of the corresponding gene. Genes can be changed, some changes will not cause changes in the quantity or quality of protein, and some will. This change in genes is called gene mutation. Changes in the quantity or quality of protein will lead to physical dysfunction and even diseases. The concept of genetic testing Genetic testing is a technology to detect DNA through blood, other body fluids or cells. Genetic testing can be used to diagnose diseases and predict the risk of diseases. Disease diagnosis is the use of gene detection technology to detect mutant genes that cause hereditary diseases. At present, the most widely used genetic testing is the detection of neonatal hereditary diseases, the diagnosis of hereditary diseases and the auxiliary diagnosis of some common diseases. At present, there are more than 1000 kinds of genetic diseases that can be diagnosed by gene detection technology. What is exciting in recent years is the development of predictive genetic testing. Using genetic testing technology, we can find the risks before the disease occurs, prevent it early or take effective intervention measures. At present, more than 20 diseases can be predicted by genetic testing. When testing, the subject's genes are first extracted from blood or other cells. Then, this part of genes can be replicated many times by primers and PCR technology, and whether there is mutation or sensitive genotype in this part of genes can be judged by mutation gene probe method, enzyme digestion method and gene sequence detection method with special markers. At present, the main methods of gene detection are: fluorescence quantitative PCR, gene chip, liquid biochip and microfluidic technology. The difference between traditional detection Our usual medical detection means is to detect the specific symptoms of the disease or the existing lesions. The development of modern science has promoted the continuous development of medical examination methods, and we can make a detailed analysis of diseases vertically or horizontally. As we all know, the basic component of the human body is cells. If we can make a substantive analysis of cells, we can find the root of the disease. For example, cancer is the result of human cell mutation and massive replication. The general medical test means is to see if there are cancer cells in your body, but there is no way to know the risk of cancer-free cells. Genetic testing can accurately tell you whether there is a possibility or probability of a disease in a certain life cycle in the future, and give you an early warning notice so as to take effective preventive measures as soon as possible. Gene gene testing, gene sequencing and physical examination What is the difference between gene testing and routine physical examination? Both disease susceptibility gene detection and routine physical examination can play a preventive role, but the stages are different. A disease takes a long time from the beginning to the onset. Genetic testing is to prevent what diseases will happen when people are not sick in the future, which belongs to the first stage of testing; Routine detection is how much the disease reaches after the disease occurs. Such as: prophase, metaphase, etc. It belongs to the second stage of detection and belongs to the category of clinical medicine. Therefore, genetic testing is to actively prevent the occurrence of diseases, and traditional physical examination methods can not play such a preventive role. Traditional physical examination is mainly aimed at the diagnosis and examination of clinical lesions that have appeared in human body. Its main task is to cooperate with the treatment of diseases, and it is impossible to predict the lesions before they occur and draw more and deeper conclusions. In other words, in the prevention of diseases, the traditional physical examination is very passive and lagging behind. In reality, many diseases have no obvious symptoms, and once they occur, modern medicine is often helpless, and patients and their families may suffer and be troubled for life. The genetic history of the disease family is caused by the inheritance of disease-prone genes, so gene detection can detect the susceptible genotypes of these genes, and the detection accuracy rate reaches 99.9999%. A total of 34 disease types (1) d were detected: Graves' disease, Hashimoto's thyroiditis, acute lymphoblastic leukemia, chronic myeloid leukemia, systemic lupus erythematosus, chronic hepatitis B, chronic severe hepatitis B, autoimmune hepatitis, posthepatitic cirrhosis, primary biliary cirrhosis, type I diabetes, Vogt- Kobayashi Harada syndrome, rheumatoid arthritis, uremia, Iga nephropathy, non-Iga mesangial proliferative nephritis, anti-glomerular basement membrane nephritis, hormone-sensitive nephropathy, renal cancer, narcolepsy, asthma, bone and joint tuberculosis (2) 9 types E: susceptibility genes for cardiovascular and cerebrovascular diseases. Hyperlipidemia, coronary heart disease, atherosclerosis, hemorrhagic stroke, ischemic stroke, atrial fibrillation, senile dementia, hypertension complicated with left ventricular hypertrophy) (3) Type V F: Susceptibility detection of diabetes and its complications (including type II diabetes, diabetic nephropathy, diabetic ophthalmopathy, diabetic cardiovascular complications and diabetic neuropathy) (4) 13 GC: Male tumor susceptibility gene Liver cancer, gastric cancer, acute lymphoblastic leukemia, chronic lymphoblastic leukemia, colon cancer, rectal cancer, laryngeal cancer, esophageal cancer, gastric ulcer, nasopharyngeal cancer, bladder cancer, prostate cancer, etc. (5) Hc 15: Detection of female tumor susceptibility genes (including breast cancer, ovarian cancer, cervical cancer, esophageal cancer, nasopharyngeal cancer, lung cancer, primary liver cancer, gastric cancer, gastric ulcer, nasopharyngeal cancer, acute lymphoblastic leukemia, chronic lymphoblastic leukemia, etc. (6) Type V X: pancreatic cancer, type II diabetic foot, allergic purpura nephritis, senile cataract and chronic bronchitis. (7) Diet intervention sensitivity of five Y-type people with endogenous hypertriglyceridemia, hypercholesterolemia, type IIb hyperlipoproteinemia and hyperlipidemia (8) Genetic detection of m 1- health and beauty of Meiyan No.1 (9) Genetic detection of M2- obesity susceptibility of Meiyan No.2.. Paternity is called paternity test or paternity test. DNA is the basic carrier of human inheritance, and human chromosomes are composed of DNA. Each human cell has 23 pairs (46 chromosomes), one from the father and the other from the mother. Twenty-three chromosomes provided by husband and wife are paired with each other after fertilization, forming 23 pairs (46 chromosomes) of children. This cycle constitutes the continuation of life. Because there are about 3 billion nucleotides in the whole chromosome system, the exchange and combination before the formation of germ cells are random, and no two people in the world have exactly the same 3 billion nucleotide sequence, which is human genetic polymorphism. Although there is genetic polymorphism, everyone's chromosome must only come from their parents, which is the theoretical basis of DNA paternity. Traditional serological methods can detect red blood cell blood group, white blood cell blood group, serotype and red blood cell enzyme type. These genetic markers are protein (including glycoprotein) or polypeptides, which are easily inactivated, resulting in unsatisfactory detection results. In addition, these genetic markers are all products of gene coding, and the content of polymorphic information (PIC) is limited, which can not reflect the polymorphism of DNA coding region, and these genetic markers have physiological and pathological variations (for example, people with type A and O blood may be positive for B antigen after being infected with E.coli). Therefore, its application value is limited. DNA test can make up for the deficiency of serological methods, so it is highly concerned by forensic material evidence workers. In recent years, the progress of human genome research is changing with each passing day, and molecular biology technology is also improving. With the continuous penetration of genome research into various disciplines, the progress of these disciplines has reached an unprecedented height. In forensic medicine, the detection of STR loci and SNP loci is the core of the second and third generation DNA analysis technologies respectively, and it is a detection technology developed after the research of RFLPs (Restrictive Fragment Length Polymorphism) VNTRs (Variable Number Tandem Repeat Sequence Polymorphism). As the most advanced criminal biotechnology, DNA analysis provides a scientific, reliable and rapid means for forensic material evidence examination, which makes the identification of material evidence transition from individual exclusion to the same level. DNA testing can directly identify crimes and provide accurate and reliable basis for solving major and difficult cases such as murder, rape and murder, dismemberment and pregnancy caused by rape. With the development and application of DNA technology, the detection of DNA labeling system will become an important means and way to solve the case. As a paternity test, this method is very mature and internationally recognized as the best method. Accuracy of paternity test DNA paternity is the most accurate paternity test method at present. If the genetic locus of the child is not consistent with that of the tested man (at least 1), then the man will be excluded from 100% blood relationship, that is, he will never be the father of the child. If the children and parents are located in the same place, we can draw the possibility that the relationship between parents is greater than 99.99%, that is, to prove the kinship between them. People with family history of cancer or polygenic diseases (such as Alzheimer's disease, hypertension, etc. ) are the most in need of genetic physical examination. Through genetic examination, these high-risk groups can know whether they have disease genes, so as to find and prevent them as soon as possible, and adjust their diet, health care and living habits to avoid the possibility of disease. Choose drugs correctly to avoid drug waste and adverse drug reactions. Due to individual genetic differences, different people will have different reactions to foreign substances (such as drugs). Therefore, some patients may have drug allergies, redness and rashes when using normal doses of drugs, or some people will feel magical when taking the same drugs, while others will not only be ineffective but also have side effects. Genetic physical examination is helpful to understand genetic constitution and predict possible drug reactions through the determination of genes related to drug reactions. Provide the best foundation for health risk management. Nowadays, many bad environmental factors, such as air, water quality and pesticide pollution, coupled with bad living habits such as smoking and drinking, can easily destroy genes in the body and cause diseases. People who have been exposed to these highly polluted environments for a long time or have bad living habits, as well as people who are in good health at present, can understand their tendency to have different diseases through genetic physical examination, and make comprehensive life adjustment or intervention, so as to reduce risks, delay the occurrence of diseases, and achieve the purpose of "personalized medical treatment and decoding health" advocated by Ji Kang. Jiaozuo Aide Health Management Co., Ltd. announces gene detection to prevent diseases.