1. student mobility: the emergence of mixed learning environment challenges the classroom learning style, and the mobility of students also makes teaching no longer pay attention to traditional theoretical courses.

2. Development of technology: The continuous development of technology contributes to the reform of chemistry curriculum, but the combination of traditional teaching methods and new technologies is still a great challenge.

3. Students' basic nursing: Because most experimental activities don't need much nursing, students may ignore some basic knowledge, which will bring great obstacles to their study.

4. The connection between theory and practice: Some learners may find that there is a big gap between theoretical courses and experimental activities, which is the challenge of integrating theory with practice.

5. Reward affirmation: Some students may not know much about this course. It is also a great challenge to guide them to actively participate in classroom activities and learn knowledge, because they may need to be praised, encouraged and rewarded in order to persist in learning and succeed.