Mycoplasma pneumoniae (MP) is an extracellular pathogen that adheres to and destroys ciliated epithelial cells on the surface of respiratory mucosa. According to the epidemiological survey of children's asthma in 2000, 90% of children's acute asthma attacks were induced by various acute respiratory infections. Mycoplasma pneumoniae and Chlamydia pneumoniae are the most important pathogens after virus, which are considered to be related to acute attack of allergic asthma in children or long-term refractory asthma and asthma deterioration.

Mycoplasma pneumonia is one of the important pathogens of respiratory tract infection in children, which is widely distributed all over the world and can occur all year round. It is reported that mycoplasma pneumoniae accounts for 10-30% of all kinds of pneumonia, reaching 50% in the peak year, and the epidemic situation lasts for 1-2 years. For children, mycoplasma infection can last for weeks, months or even years.

Characteristics of mycoplasma pneumoniae infection

Diffusion: water droplets

Incubation period: 1-3 weeks

Susceptible population: Children aged 1- 10, especially preschool children aged 1-6, have a high incidence of mycoplasma infection.

Clinical symptoms: Most mycoplasma infections have mild clinical symptoms, and are the most contagious in the early 4-6 days, and some of them will develop into pneumonia, which belongs to atypical pneumonia and can be life-threatening.

Characteristics of easy recurrence: Mycoplasma pneumoniae grows slowly, and it is easy to relapse due to incomplete treatment. Mycoplasma, as a microorganism, exists in human body for a long time. As long as the immune function is low, mycoplasma infection is easy to recur.

Complications: In addition to respiratory infection, it can also cause neurological, cardiovascular, blood, digestive, urinary and skin, joint pain, eye, nose and other multi-organ and multi-system complications.

Antibiotics: Mycoplasma is not sensitive to penicillins, cephalosporins and sulfonamides; Mycoplasma is sensitive to macrolides such as tetracycline and erythromycin, aminoglycosides such as azithromycin and kanamycin, and fluoroquinolones such as levofloxacin. However, most antibiotics sensitive to mycoplasma have great side effects on the normal growth and development of children. Therefore, macrolide antibiotics have become the first choice for clinical treatment of mycoplasma infection in children.

Epidemiology of Mycoplasma pneumoniae

Mycoplasma pneumoniae and Chlamydia pneumoniae are common pathogens in children's respiratory system, which have become important causes of allergic asthma, asthmatic bronchitis and asthma aggravation in children. It can occur all year round, but it is most common in autumn and winter, which is easy to cause widespread popularity. Most people who are willing to do this are children and adolescents, with school-age children having the highest incidence rate, followed by preschool children and young children.

Relationship between mycoplasma pneumoniae and asthma

In recent years, due to the widespread prevalence of mycoplasma pneumoniae, clinical statistics show that the incidence of bronchial asthma has greatly increased after children are infected with mycoplasma pneumoniae, which greatly increases the use of clinical hormones and makes many parents of children with pneumonia complicated with asthma worry about the side effects of hormones. Many scholars have put forward some biological mechanisms to explain the role of these atypical pathogens in the pathogenesis of childhood asthma. The mechanisms of inflammatory reaction caused by mycoplasma pneumoniae and chlamydia are similar, mainly including:

Directly manipulating the respiratory epithelium, Mycoplasma pneumoniae adheres to and fixes on the respiratory epithelium and cilia, destroying the mucosal epithelium of the respiratory tract. At the same time, Mycoplasma pneumoniae has antigen components similar to human cell membranes, thus escaping from human immune surveillance, and can exist in the human body for a long time, which is called "Mycoplasma pneumoniae immune escape", resulting in inflammation that is not easy to recover for a long time. This chronic inflammation that continues to lurk in the airway epithelium determines the histological basis of airway hyperresponsiveness.

Allergic reaction: As a specific antigen, mycoplasma pneumoniae infection, like virus, is caused by type I allergic reaction mediated by specific IgE, which leads to typical manifestations of bronchospasm, airway inflammation and airway hyperresponsiveness asthma.

Promote the release of cytokines and growth factors. After mycoplasma pneumoniae infection, it can colonize and reproduce in airway epithelial cells. As superantigen, it can induce the infiltration of inflammatory cells such as lymphocytes, monocytes and macrophages, promote the release of various cytokines and growth factors, and cause airway hyperresponsiveness.

In addition, mycoplasma pneumoniae or incomplete treatment can stimulate the body continuously, making the allergic reaction persist, which is manifested as intractable asthma attack. Therefore, for those asthmatic children who have been actively treated with bronchodilators and hormones, but their symptoms are still not well controlled, the history of mycoplasma infection should be considered at this time.

Why does mycoplasma pneumoniae infection cause allergic asthma? Recovery after mycoplasma pneumonia is very important, even more important than anti-inflammatory treatment, because it is more important to prevent reinfection of mycoplasma pneumonia and prevent infection complications. Repeated mycoplasma infection can damage airway mucosa, cause airway hyperresponsiveness, lead to chronic cough symptoms, and even lead to asthma in severe cases. If it happens to allergic children, as long as the upper respiratory tract is infected immediately, we often see that asthma is difficult to treat, but we don't pay attention to the physical recovery after repeated pneumonia. Therefore, recovery after illness is very important to prevent complications.

The repair method of mycoplasma pneumonia is to supplement Kangminyuan anti-allergic probiotics.

Kangminyuan probiotics combined with immune experiments in Xijing Hospital proved that it can inhibit airway inflammation of asthma. Kangminyuan Probiotics Enhance the Airway Protection Mechanism of Formulated Asthma Abstract: Kangminyuan Compound Probiotics (enhanced) can improve airway allergic inflammation, reduce the number of inflammatory cells in alveolar tissue (eosinophils, neutrophils, lymphocytes are significantly reduced), relieve chronic airway inflammation, induce the production of Treg cells in lung lymph nodes, promote the expression of related inhibitory cytokines IL- 10, and inhibit the expression of Th2 cytokines, thus exerting immune function. Kangminyuan probiotics enhance the protective mechanism of food allergy Abstract: Kangminyuan compound probiotics (enhanced) can reduce the content of IgE and IgG in serum, promote the production of IgA to inhibit food allergy symptoms, and induce the production of dendritic cells (DCs) of CD 103+, promote the production of regulatory T lymphocytes (Treg), promote the intestinal immune balance, and help adjust allergic constitution.

Microorganisms are invisible, so they are more magical. The regulating effect of antiallergic probiotics on allergy is a new concept that microorganisms affect diseases. Patients with recurrent respiratory tract infections and prone to recurrent cough should not adjust their physical recovery by supplementing Kangminyuan professional anti-allergic probiotics after pneumonia. It is of great significance to help children recover. Many times, after drug treatment, the symptoms are relieved, and we think that the disease is cured. The function of repair is not something that children can repair by eating, drinking and drinking well. We all know that probiotics need some unique methods. However, with the development of microecology in recent years, the functions of many new strains have become stubborn. Some people will say that my children have been eating probiotics. Probiotics are different from probiotics. Microorganisms are special substances, and different strains have different functions.

What is an antiallergic probiotic? Verification of Anti-allergic Efficacy of Kangminyuan Probiotic Formula We handed it over to Zhengzhen Medical Platform for research and inspection. The following is a two-year clinical study of Kang Minyuan's probiotic formula combined with the pediatrics department of Xijing Hospital of Air Force Military Medical University. Two published research papers have been published in international journals. One paper is: Study on the Protective Mechanism of Kangminyuan Six Probiotic Formulas on Asthma. Conclusion Summary: Kangminyuan probiotic fortified formula can improve airway allergic inflammation, reduce the obvious decrease of inflammatory cells such as eosinophils, neutrophils and lymphocytes in alveolar tissue, relieve chronic airway inflammation and inhibit allergic inflammation caused by antigen, which has a negative effect on airway inflammation. At the same time, it can induce the generation of CD 103+ dendritic cells, thus regulating the generation of T lymphocytes (Treg), promoting immune balance, and reducing the risks of food allergy and airway inflammation. Children with allergic constitution and repeated mycoplasma pneumoniae pneumonia are more likely to induce respiratory allergic cough asthma due to infection. Therefore, children with allergic constitution and repeated pneumonia should be supplemented with Kangminyuan anti-allergic probiotics after pneumonia to repair the damage caused by airway inflammation.