The scientific research project 10 was completed for the first time, and all of them passed the results appraisal, and won two third prizes for scientific and technological progress in Shanghai and three prizes for scientific and technological progress in Shanghai Health Bureau 1 item. He has been awarded the advanced family planning worker in Shanghai for many times in a row, 1998 won the China Prize for Good Birth and Excellent Child Care, and in 2004 won the Magnolia Award for Children's Work in Shanghai. Typical cases include common genetic diseases, including chromosomal diseases, monogenic genetic diseases, polygenic genetic diseases, birth defects with various morphological or functional abnormalities, diseases related to chromosomal abnormalities, and genetic eugenic cases and problems related to love, marriage and childbirth. In the long-term clinical practice, more than 20 rare chromosome syndromes, clinical syndromes, cases related to chromosome abnormalities and various genetic diseases have been discovered, and more than 60 cases of abnormal karyotypes and cases have been reported for the first time. Combined with more than 80 published papers and monographs 10, the clinical experience and experience were further summarized, popularized and applied.