Published 6 papers in important journals at home and abroad, including 3 core journals; Published 6 monographs (translations, etc.). ). 1, Surgery (National Higher Vocational and Technical Education Planning Textbook of Ministry of Health), People's Health Publishing House, 2003, editor-in-chief. 2. Surgery (National Adult Medical Education Textbook), People's Military Medical Publishing House, 2003, editor in chief. 3. Report of 8 cases of eosinophilic granuloma of skull, Chinese Journal of Neurosurgery. In 2009, first author. 4. Clinicopathological evaluation of biological behavior mechanism of pituitary adenoma, China Journal of Minimally Invasive Neurosurgery. In 2008, the second author. 5. Molecular epidemiological study of pituitary adenoma and familial pituitary adenoma, chinese journal of nervous and mental diseases. In 2008, the second author. Introduction of representative scientific research achievements: 1. The microsurgical anatomy study through the anterior approach of the corpus callosum was completed in 2004, 65438+February. The tumor in the third ventricle is deep and there are many important structures around it, which makes the operation difficult and prone to complications after operation. It is one of the difficulties in clinical treatment. ATA is mainly used to remove tumors in the anterior and middle part of the third ventricle. There are four surgical approaches to open the top of the third ventricle, and the choice of surgical approach is still controversial. In this paper, 12 corpses of China were studied in detail. This article was published in Chinese Journal of Neurosurgery, Volume 22, Issue 22, 2006, and was completed in June 2004. P27 is a tumor suppressor gene. Many tumors and proliferative diseases are related to the inactivation of p27. The level of p27 protein and mRNA in hyperplastic pituitary gland is decreased, and its regulatory mechanism is as follows: ①DNA methylation inhibits the co-expression of p27 protein and p27mRNA, leading to p27 gene silencing. ② Transforming growth factor (TGF) is enhanced by estrogen, which inhibits the proliferation of p27 cells. ③ The role of estrogen receptor, the change of estrogen concentration and its receptor expression are the pathogenesis of proliferation. This article was published in Foreign Medicine (Neurology and Neurosurgery), Volume 365438 +0, No.5..