[Abstract] Objective: To analyze the use of antibiotics in our hospital, and to provide reference for clinical rational drug use. Methods: 5809 prescriptions of western medicine, including 2736 prescriptions of antibiotics, were randomly selected from 2005 10 to June, and the types, quantities and amounts of antibiotics used in our hospital were analyzed. Results: The dosage of β -lactam antibiotics ranked first, followed by macrolides and quinolones. Conclusion: The use of antibacterial drugs in our hospital is basically reasonable, but there are also some unreasonable points, so corresponding measures should be formulated according to the existing problems. [Keywords:] antibiotics; Antibacterial activity; Rational use of antibiotics Our hospital is a second-class first-class hospital. In recent years, due to the continuous development of antibiotics, the variety and usage are increasing, which has become the most widely used drug in our hospital. However, unreasonable use of antibiotics will increase the number of drug-resistant strains and increase the economic and mental burden of patients. In order to strictly control and master the use of antibiotics and ensure the rational use of antibiotics, we made statistics, analysis and comparison on the use of antibiotics in our hospital from June to June in 2005, so as to provide guidance for the rational use of antibiotics in clinic, ensure the rational use of antibiotics and reduce the occurrence of bacterial resistance, which is conducive to the safety, effectiveness and economy of antibiotics. 1 Data and Methods 1. 1 The data source is the antibiotic delivery data in our hospital's computer management system from June to June 2005 and the related data in our hospital's antibiotic prescriptions from June to June 2005, including the types, specifications, quantities and amounts of antibiotics. 1.2 Methods A total of 5,809 prescriptions were randomly selected from June/kloc-0 to June 2005 in our hospital, including 2,736 prescriptions of five antibiotics. The composition ratio was calculated by sorting, and the consumption amount of five antibiotics was counted. Results 2. 1 prescription of antibacterial drugs accounted for 47. 1% of 5809 prescriptions, of which 189 1 prescription of antibacterial drugs alone and 845 prescriptions of combined antibacterial drugs. The prescription containing β -lactam antibiotics ranks first among antibiotics, because β -lactam antibiotics are harmful to gram-positive bacteria, negative bacteria and some anaerobic bacteria. 2.2 Sales Amount of Antibiotics Among the 2,736 prescriptions sampled, the sales amount of drugs * * * was 673 166.30 yuan, of which the sales amount of antibiotics was 306,097.20 yuan, accounting for 45.47% of the total sales, and the sales amount of β -lactam drugs ranked first. See Table 2 for details. Table 2 Sales Amount of Various Antibiotics 3 Discussion Through analysis, it can be seen that the number of prescriptions and sales of β -lactams are more than other anti-infective drugs. Penicillin antibiotics and cephalosporins are commonly used in clinic. The use of new β -lactamase inhibitors makes β -lactam drugs more active, bacteria are not easy to produce drug resistance, and have low toxicity, wide indications and good curative effect, which has been widely used in clinic. The dosage of macrolide antibiotics is second only to β -lactam antibiotics in clinic. Erythromycin and other drugs have good antibacterial effects on gram-positive bacteria, negative cocci and anaerobic bacteria. Used in clinical treatment of respiratory tract infection, with definite curative effect and no serious adverse reaction. However, erythromycin has a relatively narrow antibacterial spectrum and low bioavailability, so its clinical application is limited. Roxithromycin, clarithromycin and azithromycin have enhanced antibacterial activities against influenza Bacillus and Neisseria gonorrhoeae, are not easily destroyed by gastric acid, have high bioavailability, long half-life and correspondingly reduced adverse reactions, and are welcomed in clinic. Quinolones are also popular in recent years, especially the third generation quinolones, which are well absorbed in the intestine, easily absorbed by oral administration, widely distributed, strong antibacterial activity and relatively long half-life. Therefore, in the treatment of systemic infections, they are often used as substitutes for penicillin and cephalosporins, which are not suitable for children and pregnant women. The application of aminoglycosides is limited because of their ototoxicity and nephrotoxicity. Bacterial aminoglycosides can produce drug resistance, which is ineffective for anaerobic bacteria and is rarely used in clinic. However, aminoglycosides and β -lactams have synergistic effect and can be used to control serious infection. It is also an important anti-infective drug in clinic, and other antibiotics such as tetracycline and chloramphenicol are rarely used in clinic. Conclusion The use structure of antibacterial drugs in our hospital is basically reasonable, but there are also some unreasonable points. The anti-infective drugs used by clinicians are mostly empirical drugs. All departments in the hospital should make the list of antimicrobial agents and the administration plan according to their own specific conditions, check the feedback regularly, guide the rational use of antimicrobial agents, effectively promote the safe, effective and economical use of antimicrobial agents, reduce the economic burden for the country and patients, and further improve the level of rational use of antimicrobial agents in clinic. I hope my answer is helpful to you. . . . . . .