The author's signature must be agreed in advance to avoid future trouble. There are many disputes caused by improper signature, and many of them often withdraw their manuscripts on the grounds of moral anomie.

When submitting the first draft, the author basically needs to check the options in an online system to confirm that "all research participants have been included in the author's signature column", "all authors know about this submission operation", or something similar. The purpose of this process is to ensure that all research participants who have the right to sign are authors, and that all authors know and agree to this submission.