The invention relates to a multi-grain brewing method of Luzhou-flavor Xiaoqu liquor, which is mainly characterized by the following grain varieties and their weight percentages: sorghum 40-60%, rice 15-20%, glutinous rice 5- 10%, corn10/5%. Sorghum and corn are mixed, and rice, glutinous rice and buckwheat are mixed, classified and soaked; Then cook in stages. The multi-grain Luzhou-flavor Xiaoqu liquor brewed by the method of the invention is colorless and transparent, fragrant and elegant, mellow, sweet and soft, sweet and clean, natural and harmonious, pleasant in aftertaste, and has a typical flavor of complementary multi-grain and fragrance; Compared with single-grain fragrant Xiaoqu liquor, the contents of ethyl acetate and ethyl lactate were significantly increased, while the content of fusel oil was significantly decreased, and its aroma and flavor were more intense, with a sweet and mellow aftertaste.