This paper reveals the research results of centralized follow-up of 1733 patients discharged from Wuhan Jinyintan Hospital from June to September, 2020. The paper found that more than three-quarters of patients with coronavirus pneumonia-19 reported that they still had at least one symptom, such as fatigue or muscle weakness, six months after the onset.
According to the above-mentioned concern statement of the editorial department of The Lancet, the editorial department of The Lancet learned on June 7, 2022 that "some variables in the data set were wrongly out of order" after asking the correspondent. "In view of the extent of these data errors, we now issue a statement of concern about the' 6-month' paper and will conduct further investigation, including further statistics and clinical review of corrected data."
165438+2022124 October, a statement of concern issued by the editorial department of The Lancet, an international medical journal.
The title of this paper is "Six-month clinical results of discharged patients in COVID-19: a cohort study", which was published online in The Lancet on 2002118.
The article points out that the contributions of Cao Bin, Zhang and Wang Jianwei are the same. King Cao is the reporter mentioned in the newspaper.
Among them, King Cao signed contracts with China-Japan Friendship Hospital, Department of Respiratory and Critical Care Medicine, National Respiratory Disease Clinical Medical Research Center and National Respiratory Medical Center.
According to the information published on the website of China-Japan Friendship Hospital1October 200211,the above research was jointly completed by Wuhan Jinyintan Hospital, the Respiratory Center of China-Japan Friendship Hospital, the National Respiratory Medicine Center and the Institute of Pathogenic Biology of China Academy of Medical Sciences. Huang, Huang, Wang, Li Xia, Ren Lili, Gu Xiaoying, Kang Liang and He are the first authors. This study evaluated the long-term results of coronavirus pneumonia-19. "The study found that 76% of patients still have at least one persistent symptom after 6 months of onset. Fatigue and muscle weakness are the most common symptoms, and sleep disorders, anxiety and depression also occur frequently. "
"Professor King Cao from China-Japan Friendship Hospital and National Respiratory Medicine Center of Capital Medical University said:' Because coronavirus pneumonia-19 is a new disease, we are just beginning to understand its long-term impact on patients' health. Our follow-up study shows that most patients will continue to be affected by at least some viruses after discharge, and medical care after discharge is very necessary, especially for patients who are seriously ill when they are hospitalized. Our research also shows the importance of long-term follow-up study in a larger population to understand the possible comprehensive impact of the disease on the human body. This follow-up study was completed from June 16 to September 3, 2020, and selected 1733 patients discharged from Wuhan Jinyintan Hospital from October 7 to May 29, 2020. The median age of the patients was 57 years old, and the median follow-up time was 186 days after onset. The above information on the website of China-Japan Friendship Hospital said.
The editorial department of The Lancet pays attention to the articles targeted by the statement. According to this paper, follow-up found that 76% of COVID-19 patients still have at least one persistent symptom after 6 months of onset.
The authors of the above papers are: Chao Linhuang, Li Xuehuang, Ye Mingwang, Li Xia, Li Liren, Xiaoyinggu, Liang Kang, LiGuo, Liu Min, Sin Chew, Jian Fengluo, Huang Zhenghui, Sheng Jintu, Yue Zhao, Li Chen, De Cuixu, Li Yanping, Rainbow Li, Lu Peng, Li Yong, Wuxiangxie, Dan Cui, Lian Hanshang and Guo Huifan.
What are the long-term symptoms of COVID-19?
About one month before the publication of the above paper, in February 2020, the international medical magazine The Lancet published an editorial saying, "Face COVID-19's long-term symptom dilemma", and said that at the 2020 "The Lancet-China Medical College Health Conference" held at the end of June 2020, "King Cao introduced Wuhan coronavirus pneumonia-. We call it' COVID-19's long-term symptoms', which is a rapidly developing medical problem and needs immediate action. "
Seven months after the publication of the above papers, in August of 20021,King Cao, Wang Jianwei and others published the research results of Wuhan jinyintan hospital 1276 patients discharged for one year in The Lancet. They found that "the proportion of patients with at least one sequelae symptom decreased from 68% at 6 months to 49% at 12 months."
The title of this paper is "Clinical Outcome of Survivors in COVID-19 in 1 year: A longitudinal cohort study".
One-year follow-up study of 0/276 discharged patients in COVID-19/KLOC.
However, the paper was corrected after it was first published. The corrected version was first published on the website of The Lancet on May 5, 2022.
It is worth noting that the above-mentioned "Six-month Paper" mentioned that six months after COVID-19's onset, 76% of the survivors reported at least one symptom. The relevant proportion mentioned in the above "1 paper" is 68%. The Lancet has not disclosed whether the "inconsistent data" mentioned in its concern statement is this ratio.
The above statement of concern issued by the editorial department of The Lancet on June 24, 2022 +065438+ said, "After receiving an inquiry from a researcher about the inconsistency of the data in these two articles, we sought an explanation from the correspondent of these two articles. On June 7, 2022, the editorial department of The Lancet was told that the data of' 6 months' and' 65,438+0 years' were inconsistent because some variables in the data set used in the' 6 months' paper were out of order. In view of the extent of these data errors, we now issue a statement of concern about the' 6-month' paper and will conduct further investigation, including further statistics and clinical review of corrected data. If there is more information, we will update this notice immediately. "
In addition, on May/KOOC-0//KOOC-0/,2022, King Cao and Wang Jianwei, as * * * co-authors, published a paper online in the international academic journal "The Lancet Respiratory Medicine", reporting the research results of/KOOC-0//KOOC-0/92 discharged patients in Wuhan Jinyintan Hospital for two years.
According to this paper, from June 7th to May 29th, 2020, 2,469 COVID-19 patients were discharged from Wuhan Jinyintan Hospital. Among them, 1 192 people completed the evaluation in three follow-up visits and were included in the final analysis; 94% people, 1 1 19 people participated in face-to-face interviews two years after infection. Generally speaking, two years after the first infection, the health status of recovered patients in COVID-19 is still worse than that of the general population, which means that some patients need longer time to fully recover. "In COVID-19, the proportion of survivors who still have at least one symptom has dropped significantly from 68% at six months to 55% at two years. Fatigue or muscle weakness are the most common symptoms. "
The title of this paper is "Two-year health outcomes of hospitalized survivors in COVID-19: a longitudinal cohort study". The study was reported by the media as "the longest follow-up in COVID-19".
Two-year follow-up study of 92 discharged patients in COVID-191/KLOC-0.
In addition, according to the news released by The Lancet on the official WeChat account, in July 1 day, the magazine published an observational study targeting more than 70,000 people in 302 hospitals in the UK, and found that one in every two hospitalized patients with coronavirus pneumonia-19 would have at least one complication. "Professor King Cao and Gu Xiaoying from China-novel coronavirus Friendship Hospital wrote in their comments:' Considering that there are a large number of Japanese infected people in the world, the public health impact of coronavirus pneumonia-19 in the acute phase is enormous. In addition to analyzing the manifestations of the whole clinical disease spectrum after coronavirus pneumonia-19, it is necessary to carry out further research in different populations and people with clinical characteristics to clarify the pathophysiological mechanism of coronavirus pneumonia-19 in the acute phase, especially in the long term. In addition, it is necessary to study the serological characteristics of coronavirus pneumonia-19 and the influence of immune abnormality and inflammatory damage caused by acute novel coronavirus infection after acute or long-term treatment. "
Official website of China-Japan Friendship Hospital shows that King Cao, chief physician, professor and doctoral supervisor, is good at the diagnosis and treatment of respiratory infections; He is currently the vice president of China-Japan Friendship Hospital, director of respiratory and critical care medicine, director of respiratory and critical care medicine, director of the management committee of the Institute of Clinical Medicine, executive deputy director of the National Respiratory Medicine Center, and deputy director of the Institute of Respiratory Medicine of China Academy of Medical Sciences; He is a member of the International Society of Influenza and Respiratory Virus Infection, deputy editor of the Journal of Clinical Respiratory, member of the editorial steering committee of the International Journal of Infectious Diseases, and member of the editorial boards of the Chinese Medical Journal and the Chinese Journal of Tuberculosis and Respiratory Diseases.
Official website of Peking Union Medical College of China Academy of Medical Sciences shows that Wang Jianwei is a researcher, professor and doctoral supervisor; Since February 2006, he has served as an associate researcher, researcher, professor and doctoral supervisor at the Institute of Pathogenic Biology, Peking Union Medical College, China Academy of Medical Sciences, director, assistant director and deputy director of Christopher Meria Laboratory, and director of the science and technology management department of the university. 2065438+In June 2009, he served as vice president and member of the Standing Committee of the Party Committee.
According to the above information, Wang Jianwei is mainly engaged in the research on the pathogenesis and prevention of important respiratory virus infections, and has been supported by many talent programs. Member of the overall group of major scientific and technological projects for the prevention and treatment of major infectious diseases such as AIDS and viral hepatitis, and member of the key expert group for the research and development of key technologies for biosafety; He is the executive director of the Sixth Council of the Chinese Preventive Medicine Association and a member of the Biosafety and Health Committee. Executive editor of health magazine.