Improve the existing scientific and technological achievements, further develop DNA and protein staining detection technology, and solve the existing problems in this field. Focus on the development of dyeing detection technology with high sensitivity and compatibility with mass spectrometer. When the conditions are ripe, it will be industrialized and open up domestic and foreign markets.
In the technical link of new drug research and development, we should give full play to our dual advantages and effectively combine pharmacy (especially traditional Chinese medicine), cell molecular biology and protein omics, so as to improve the efficiency of drug research. In this respect, there should be a very broad research prospect. As we all know, our Chinese medicine has a fatal weakness, which limits its development. This weakness is that the composition is complex, especially after a series of processing and extraction, the composition is difficult to predict, and it is difficult to reach the level of western medicine research (accurate qualitative and quantitative). If we adopt the method of learning western medicine (finding one or more effective ingredients), it is difficult to give full play to the advantages of traditional Chinese medicine compound. Protein omics combined with molecular biology and traditional Chinese medicine can skip these complex composition changes to study traditional Chinese medicine. No matter how complex the components acting on organisms are, they are ultimately composed of protein (including enzymes and their related reactants and products) that affect organisms. Only in this way can we study Chinese medicine at the level of protein. It can also be directly compared with western medicines with similar curative effects to compare their advantages and disadvantages. Reverse thinking is used to find out the mechanism of drug action, especially for compound preparations with complex components and definite curative effect. If a breakthrough can be made, it will make great contributions to the internationalization of traditional Chinese medicine.
The specific research fields of protein's omics are briefly described as follows:
1. Combined with the technology of cell molecular biology, the protein changes of biological cells treated with various drugs (especially traditional Chinese medicine compound) were compared.
2. Infer the metabolic pathway of organisms through the determination of protein Group.
3. Combined with cell molecular biology technology, we can clearly understand pathological protein (such as cancer cells) and infer its pathogenic mechanism. Most human diseases can be found in genes. If we can find the location of pathological genes, the treatment of this disease will advance by leaps and bounds.
4. Make use of the powerful function of protein's omics to carry out extensive cooperation with many disciplines (including source identification of various animals and plants; Protein changes in various growth stages and parts of organisms, etc. ).