There are many factors that affect the onset of rabies after being bitten:

1. It depends on the number of rabies virus entering the human body. If a mad dog bites at the early stage of the disease, the rabies virus in its saliva is less than that in the later stage;

2. Whether the bite is serious also affects whether the bitten person gets sick. A deep bite in a large area is more likely to get sick than a shallow wound in a small wound;

3. Multi-site bites are also more likely to occur than single-site bites, and the incubation period is shorter.

4. Treating the wound correctly and timely after being bitten is the first line of defense for rabies. If the wound is treated correctly in time and after anti-rabies exposure, the risk of the disease can be greatly reduced.

5. Mucosal infection is more difficult to get sick than biting skin infection, and more cases are depressive rabies.

6. The incidence and mortality of wild animals biting the head, face, neck and other parts close to the central nervous system or parts rich in peripheral nerves are higher than those biting limbs.

7. People with low resistance are more likely to get sick than those with strong resistance.

Extended data:

After injecting rabies vaccine, you should pay attention to rest to avoid fatigue or taking part in strenuous exercise; You should also avoid alcohol, strong tea and other irritating drinks or foods. Hormone, cyclophosphamide and chloroquine may reduce the preventive effect of rabies vaccine and should be avoided as far as possible.

A few people get sick and die after being bitten because the vaccine can't guarantee the effectiveness of 100%. In addition, it is also related to the following factors:

Failing to treat the wound timely, effectively and correctly.

2. The severely bitten person did not use antiserum or HRIG as required, or used it too late.

3. Inappropriate vaccination methods.

4. There is something wrong with the quality of the vaccine.

5. After inoculation, drink a lot of alcohol, drink strong tea or eat irritating food, use certain drugs, engage in strenuous exercise and fatigue; Some people have slow immune response, immune deficiency, use immunosuppressants, suffer from malignant tumors, liver cirrhosis and emotional instability.

6. Vaccine strains are not completely consistent with epidemic strains. To this end, all relevant departments should implement a strict dog management system and vaccinate domestic dogs according to regulations. Prevention and control should be done from the aspects of dog management, vaccination, diagnosis and treatment to curb the rising trend of rabies epidemic.