Since 1978, he has been mainly engaged in the prevention and treatment of viral hepatitis and clinical research of vaccines, presided over and participated as a major member in the national epidemiological survey of viral hepatitis of the Ministry of Health. Participated in national key scientific and technological projects such as the Seventh Five-Year Plan, the Eighth Five-Year Plan, the Ninth Five-Year Plan and the Tenth Five-Year Plan, such as Study on Immune Persistence and Preventive Effect of Blood-borne Hepatitis B Vaccine, Study on Immune Effect of Standardized Live Attenuated Hepatitis A Vaccine, and International Project on Immune Model of Hepatitis B Vaccine in Longan County, China, and presided over the clinical research project of 10 vaccine. Starting from 1980, * * won the second prize of national scientific and technological progress, provincial and ministerial scientific and technological progress 12 and departmental scientific and technological progress 12. At present, the research projects include "Study on Immune Effect and Enhanced Immune Effect of Hepatitis B Vaccine" (National Tenth Five-Year Key Project), "Study on Safety and Immunogenicity of Inactivated Polio Vaccine", "Study on Safety and Immunogenicity of DTP-Haemophilus influenzae Combined Vaccine", "Study on Experimental Animals of Varicella Vaccine" (National Research Center for Diagnostic Reagents and Vaccine Engineering Technology) and "Immunology of Chronic Infection of Hepatitis B Virus". He has published more than 100 papers in domestic and foreign journals, including 2 papers in international authoritative magazines Vaccine and Emerging Infectious Diseases.