1978 ~ 1982 Bachelor of Pharmacy, West China University of Medical Sciences
1983 ~ 1984 Peking union medical college &; Advanced student of China Academy of Medical Sciences
From 2004 to 2004, he was a doctoral student majoring in microbiology and biochemistry at China Pharmaceutical University.
1982 ~ 1998 Peking union medical college &; The Institute of Blood Transfusion of China Academy of Medical Sciences is an intern researcher, assistant researcher, associate researcher and researcher.
1999 ~ director of biopharmaceutical teaching and research section, West China College of Pharmacy, Sichuan University.
Academic part-time:
He is a director of China Branch of Industrial Biochemistry and Molecular Biology, a member of the professional committee of medicinal chemistry of Sichuan Pharmaceutical Association, and the editorial board of professional academic magazines such as pharmaceutical biotechnology and Journal of Thrombosis and Hemostasis. Outstanding experts with outstanding contributions in Sichuan Province, peer review experts from the Ministry of Health and the Ministry of Education.
research direction
1. Study on Genetic Engineering Drugs
2. Study on natural biochemical drugs (including microbial drugs)
3. Design of engineering drugs in protein.
Main research topics and achievements
1. Study on targeted drug delivery system of nitric oxide synthase gene mediated by immune liposomes (National Natural Science Foundation of China Project 30070900).
2. Project leader of the international cooperation project of genetic engineering insulin research.
3. Project leader of preparation and application of hematoporphyrin targeting vector (commissioned scientific research project)
4. Project leader of screening and separation of myxobacteria (self-raised scientific research project)
5. The person in charge of the research on the purification of polymerized human hemoglobin solution and virus inactivation technology (cooperative scientific research project).
6. Study on monoclonal antibody against human IgGγ chain and its application in detection of humanized monoclonal antibody against VEGF (project leader of cooperative scientific research project)
In 2003, he obtained 1 invention patents in China, and applied for 2 invention patents in 2004, which have been accepted by China Patent Office.
representative works
1. Rational design and engineering of pharmaceutical biotechnology in protein 2005; 12③ 190 First author
2. Quality Analysis of Single-component Insulin Preparation, Journal of Sichuan University (Natural Science Edition), 2005; 42( 1) 175 communication project leader
3. Preliminary study on thrombolytic characteristics of Bacillus subtilis thrombolytic enzyme mutated by1strain in vitro and in vivo: Journal of Sichuan University (Medical Edition) 2005; 36( 1)93-96 First Author Project Leader
4. Preparation of Recombinant Human Insulin-Study on Downstream Purification Process Journal of Biomedical Engineering 2004; 2 1 (5): 805 First author, project leader
5. Preparation and purity identification of tert-butyl threonine ether Chemical research and application 2004; (16) Contact the first author at 5: 695.
6. Improvement of preparation technology of high-purity heme Journal of Sichuan University (Medical Edition) 2004; 35 (5): 738 Contact the project leader.
7. Rapid preparation of immobilized trypsin 2004 by biotechnology; 14 (3): 26 contacts
8. Enhanced expression of (his)6-arg-arg- human pro insurance pharmaceutical biotechnology 2003; (10) 3: 144 contact person
9. Batch preparation method of coagulation factor IX complex concentration chinese journal of modern applied pharmacy Journal 2003,20 (6): 406 First author.
10. Evaluation of the potential thrombogenicity of coagulation factor ⅸ complex in non-stasis model of rats. China Journal of Pharmacology and Toxicology 2002, 16 (2): 206 First author.
1 1. Research progress of anti-tumor effect of snake venom biotechnology newsletter 2002,3 (6) 473
Participate in teaching materials
1. Wu, editor-in-chief, Biochemistry (fifth edition for pharmaceutical use), People's Health Publishing House, 2003 (chapter III of chemistry in protein and chapter X of catabolism in protein).
2. "Introduction to Biotechnology and Pharmacy" edited by Yao Wenbing (pharmacy major) China Medical and Health Science and Technology Press 2003 (Chapter III Genetic Engineering and protein Technology and Chapter VII New Development of pharmaceutical biotechnology)
3. Modern Pharmaceutical Experiment Course 2003 compiled by West China College of Pharmacy, Sichuan University (participating in basic biochemical experiments and innovative experiments).
4. Selected Reading of Pharmaceutical English compiled by West China College of Pharmacy, Sichuan University (200 1).
Teaching reform projects and achievements
1. Directed Zhang Tao, a pharmaceutical undergraduate in 2002, to study the technology of co-production of cholic acid and bilirubin, and won the third prize of excellent graduation thesis of Sichuan University in 2002.
2. Instructed Xiong Shijuan, a pharmaceutical undergraduate in 2003, to win the third prize of excellent graduation thesis of Sichuan University in 2003 for "Screening of myxobacteria and preliminary study on their separation and purification".
3. Two teaching papers were published in Research on the Development of Higher Education (No.2, 2003), namely, Preliminary Exploration on the Discipline Construction of Microbiology and Biopharmaceutical and Reflections on the Management and Construction of Biopharmaceutical Teaching Laboratories.