A lot of research work has been done on the material surface modification, aspheric design, visual quality and biological evaluation of rigid oxygen-permeable contact lenses (RGP), and a new aspheric design rigid oxygen-permeable contact lens with biological activity and high surface performance has been developed. Related technologies and products have been transformed in enterprises, and obtained three SFDA certificates for medical devices. As the person in charge, he completed the National Natural Science Foundation project "Experimental Study on Ultra-precision 3D Surface Reconstruction of Rigid Oxygen Permeable Contact Lens" (30970884) and the key project of Zhejiang Science and Technology Plan "Development of New Aspheric Contact Lens with High Oxygen Permeability" (2006c211). Zhejiang Qianjiang Talent Plan Project "Research and Preparation Development of Amphiphilic Block Sustained-release Nanocarriers for Ophthalmology" (2008R 1004 1) and Wenzhou Science and Technology Plan Key Project "Development of Plasma Membrane Aspheric Rigid Contact Lens with High Oxygen Permeability" (G20060 147), As the sub-project leader, he completed the key project of the National 863 Program "Development of new technologies and therapeutic products for ophthalmic tumor gene therapy" (XWH08002 is the main research backbone of the project, He has successively completed the key project of National Eleventh Five-Year Science and Technology Support Plan "Bioactive Alternative Materials and Products for Ophthalmic Repair" (2006BAI 16B06), the key project of National 863 Plan "PEG-PLGA Block Copolymer with High Targeting Nano-preparation" (2007AA02 1807) and the key scientific and technological project of colleges and universities in Zhejiang Province "Low Temperature Plasma Treatment". Sports visual direction undertakes the key projects of the State Sports General Administration 1 Olympic Games.