65438-0984 obtained a master's degree in microbiology and immunology from Harbin Medical University, and 65438-0982 has been a lecturer in the teaching and research section of microbiology and immunology from now on. 1993 received a doctorate in biomedicine from the University of Montreal, Canada. The differentiation of B cells and the roles of IL- 12 and IL-4 in the differentiation of human Th 1 and Th2 were expounded. 1993- 1996 worked as a postdoctoral fellow in Hoffmann-LaRoche Inc, USA, devoted himself to the research on the expression and regulation of IL- 12 receptor, and established the IL- 12 receptor gene knockout mouse model for the first time. 1997 1 As a researcher and lifelong scientist in the National Institutes of Health (NIH), Institute of Allergy and Infectious Diseases (NIAID), clinical research laboratory and vaccine research center, I was mainly engaged in the exploration of new immunization strategies, research and development of new vaccines, immunological evaluation of vaccines, factors affecting T cells and memory T cells and immune factors affecting the progress of AIDS patients. At the beginning of 2003, he was hired by Sun Yat-sen University. He has published more than 65,438+000 monographs in famous journals at home and abroad, including more than 50 famous foreign journals, including 65,438+0 in Nature Immunology, 65,438+0 in Journal of Clinical Investigation, 4 in Journalof Immunology and 4 in EUR. Journal of immunology. In the field of international immunology, the biological function of IL- 12 receptor in vivo was confirmed for the first time, and the diversity of Th 1 cells in vivo and the formation mechanism of memory T cells were revealed for the first time. This discovery promoted the study of CD4+T cells with specific memory, clarified the formation mechanism of memory Th 1 cells in vivo, and laid a theoretical foundation for disease treatment and vaccine design. After the publication of this research result, three world-renowned immunologists, A.Abbas, D.Farber and L.M.Bradley, spoke highly of it, and their comments and news were published in NatureImmunology, TrendsImmunology and Trends Mol respectively. They are Med. Therefore, it won the second place in the best cytokine paper of 200 1-2002 by scientists from the National Institutes of Health (NIH). At present, the research directions are: (1) the formation of immune memory cells, the discussion of factors affecting immune effect and immune memory; (2) Discuss immunization strategies and research and develop vaccines; (3) Evaluation of vaccine immune effect.