I have known him since the spring of 1946. After the Japanese surrender, China Medical University in Yan 'an was ordered to move to the northeast. When passing through Zhangjiakou, it was temporarily merged with our school because the Kuomintang reactionaries launched a civil war. He was a student in Class 20 at that time. Everyone commented that he was energetic, intelligent and versatile, and he was the propaganda minister of the Student Union. But in my memory, he was still a "bumpkin" at that time, and soon they went to the northeast. 1954 When I saw him again in the Soviet Union, the former "bumpkin" became a gentle scholar. When I saw him again in the 1970s, he was already a famous expert in thoracic surgery in Beijing. It is often seen in academic exchanges of acupuncture and anesthesia in the future. He personally experienced appendectomy under acupuncture anesthesia, and his child was also born by caesarean section under acupuncture anesthesia. It can be regarded as a rare expert who personally tastes the taste of pears and promotes the research of acupuncture anesthesia. Then in the 1980s, in the China-Japan Friendship Hospital, he was the dean and I was his subordinate. But what left a deep memory for me was not Xin's childbearing age before or when he became dean, but two things he personally experienced in scientific research cooperation after he became dean. One is "Research on Kecan785 1", and the other is his "Electrochemical Treatment of Cancer".
Because we have all experienced the training in the revolutionary war years, we are all overseas students sent by the party and the people to the Soviet Union for further study, and we have also experienced the extraordinary period of the Cultural Revolution. Nowadays, in the era of reform and opening up, the arrival of scientific research spring makes us have the desire to actively invest. How to carry out scientific research under the new situation has become our common problem and naturally come together.
At that time, the wave of reform and opening-up has rushed to the reform of scientific research system in the field of scientific research, which is reflected in the selection of scientific research topics and the financing of scientific research funds. Self-financing for self-selected topics has become a fashion. Xin, who used to be the first president of the China-Japan Friendship Hospital, followed the trend and began to consider whether it was possible to introduce an anticancer drug named "Echo 785 1" used by folk doctors Liu and Liu Tongqing for many years. Part of drug income can be used as scientific research funds, which is a way of working with guaranteed funds and quick results. He suggested that I take part in the work, and I accepted his suggestion happily. It can be said that under his guidance, I stepped into the door of cancer research.
But how to start? First of all, we must find out what medicine it is. At that time, the cooperators refused to tell us clearly, and we couldn't do it blindly until we found out. What shall we do? We take this medicine to China Institute of Atomic Energy and ask them to use the most advanced neutron activation technology at that time to help us analyze it. When I learned that this is an "anti-cancer drug" which is a combination of copper and iron compounds and some Chinese medicines, I became interested in it because it is a product of the combination of Chinese and Western medicine. If it is really effective, it is meaningful to discuss its mechanism, which can be used as a doctoral thesis topic. Shao, deputy chief technician of the research group, and Du Haoping, chief technician, immediately conducted a toxicity test on the drug. Associate researcher Chi Yongchun and I led the technicians to do an experiment on the anti-tumor effect of the drug on tumor-bearing mice, and soon got a happy result. The drug has no obvious toxicity, but it does have certain anti-tumor effect. Whether it can be tried out in the outpatient department of China-Japan Friendship Hospital needs the approval of hospital leaders. Fortunately, then President Chen Shaowu was an enlightened president and an enthusiastic pioneer of reform and opening up. Under his leadership, it passed quickly. Headed by chief physicians Feng Erlu and Liu Tongqing, they began to treat patients in the outpatient department of China-Japan Friendship Hospital. Professor Xin Lvyu personally inspected the gate. He is an authoritative expert engaged in cancer medical treatment and scientific research for many years. If we can get his affirmation, it is undoubtedly credible. He asked for rigorous, meticulous and objective observation of every patient. Pay serious attention to the "curative effect" and "toxic side effects" of each patient. Chi Yongchun and I continued the animal experiment of "Kecan 785 1" on anti-tumor effect and mechanism. The anti-cancer effect and mechanism of "Kecan 785 1" were confirmed from different levels. Including: 1, the direct killing effect on cancer cells, the shedding of cancer cells' villi, the damage to cancer cells' nucleus, cytoplasm, mitochondria and heterochromatin during the killing process, until the disintegration and destruction of cancer cells. 2. The DNA synthesis of cancer cells is inhibited, which leads to the decrease of DNA content of cancer cells, the peak of ploidy map obviously shifts to the left, and the division index of cancer cells decreases. 3. From the gene level, anti-cancer genes can be enhanced and the expression of oncogenes can be inhibited. The work is progressing rapidly and smoothly.
I have to admit that this work can have the opportunity to enter the door of China-Japan Friendship Hospital. Without the selfless and fearless spirit of Professor Xin Youyue who dares to break through the traditional resistance, it is impossible. After ten years of clinical observation and experimental research, it is not smooth sailing. There are all kinds of criticisms, both good and bad. However, under the leadership of Xin, the perseverance to solve all kinds of problems in time and never give up until the goal is reached gave the research group confidence and strength. This "Clinical Efficacy and Experimental Study of Kecancer 785 1" won the second prize of state administration of traditional chinese medicine Science and Technology Progress Award 1990. In March, 199 1 was reported to the drug administration of the Ministry of Health for approval as the third kind of anti-tumor Chinese medicine, and was given the instruction of "agreeing to carry out clinical research", clearly indicating the materials that need to be supplemented. Everyone is very happy, because it is an affirmation of our efforts in the past ten years. But for various reasons, it didn't go on. With the death of Dean Chen Shaowu, Liu Tongqing left the China-Japan Friendship Hospital, and this work stopped. Today, Liu has left with regret. Liu Tongqing returned to his hometown in Anhui and got local support. In the same year, he repeated the experiment and got similar results. He was allowed to be used in clinic and has seen the effect. I believe that he will succeed sooner or later.
Another thing is the "electrochemical treatment of cancer" that Xin Childbearing Age is striving for. Inspired by international academic exchanges, this is a cancer treatment method developed by him, which has treated tens of thousands of cancer patients, especially hemangioma patients, and sent beauty and happiness to many patients with facial hemangioma. Although I am not a specific participant in this work, I am a "witness" of the whole process. In the course of more than ten years, I was moved by his active exploration, hard study and perseverance, and became a "volunteer" in this work. I helped him receive cancer patients from many countries who came to the hospital for treatment; He went to Germany, Poland, Denmark and other countries to participate in academic exchanges; He gave academic reports at the first and second World Cancer Conferences in Australia, and I helped him translate in English. He once gave lectures in Indonesia and Thailand, treated cancer patients and tried his best to help his graduate students solve problems.
In this process, I gradually formed some views on this work. In my opinion, his name of "electrochemical treatment of cancer" should be changed to "electroacupuncture treatment of cancer". It is more appropriate to classify its attributes into the category of acupuncture and moxibustion treatment in the motherland. It should be regarded as a breakthrough achievement in the field of acupuncture based on a large number of scientific experiments and tens of thousands of clinical practices. Electroacupuncture can treat tumors scientifically and effectively, which was unimaginable in the past, and now it has been successfully realized. Needle insertion can be accurately positioned, stimulation intensity, action time and treatment range can be selected, and the treatment effect can be visualized. This is unprecedented in the past acupuncture treatment of diseases. In the field of acupuncture, acupuncture anesthesia once shocked the world, and now acupuncture treatment of cancer should also have a certain shocking effect! From the formation of treatment ideas to the birth of computer-controlled treatment instruments, to the use of needle electrodes and perfect operating procedures, isn't this enough to show that it is a leap in the field of acupuncture treatment?
Although this achievement was inspired by the experimental results of Swedish scholar B.Nordenstrom who inserted needle electrodes into tumors to kill tumor cells, Comrade Xin Ziyue was able to form research ideas so quickly, developed instruments with China characteristics, successfully conducted animal experiments, and quickly applied them to clinic, also because of his inherent knowledge and academic thinking mode. This is due to the great treasure house of traditional Chinese medicine. Because Xin Ziyuan is an expert who grew up in the soil of China, she has rich experience in tumor treatment and a deep understanding of lung surgery under acupuncture anesthesia. All these have exerted a subtle influence on him, which will be instinctively reflected in his medical practice and inevitably reflected in his "electrochemical treatment of cancer". In fact, he made great strides on the road of developing Chinese medicine, and achieved scientific research results with China characteristics. It should be said that the electrochemical cancer therapeutic instrument developed by Xin Ziyuan is a leap of electroacupuncture therapeutic instrument, and the electrode used is a development of needle tools. Acupoint belongs to Ashi point in traditional acupuncture, which is similar to the positioning of fire needle application. But the fire needle can only be limited to one point, and the range of electroacupuncture can be adjusted at will. Fire needle cannot be quantified, but the intensity of electroacupuncture is up to you. However, from the beginning, this book was positioned as a treatment method introduced from abroad, ignoring its nature in the field of acupuncture in the motherland, so it was not understood, understood, recognized and valued by the acupuncture community of traditional Chinese medicine. When writing this story, I sorted out my own views and had a frank exchange with Professor Xin Luyu, and I was glad to get his approval. I believe it will be gradually recognized by colleagues in the acupuncture field.