How many times do test tubes usually succeed? Are IVF smart when they grow up? You should know the truth! "Test-tube baby" is not a baby who really grows up in a test tube, but takes out several eggs from the ovary, combines them with the man's sperm in the laboratory to form an embryo, then transfers the embryo to the uterus, implants it into the mother's uterus, gets pregnant and finally gives birth healthily. Imagine if the sperm and eggs of both men and women are of poor quality, just as low-quality seeds and high-quality full seeds can produce the same seedlings? The answer is no, inferior seeds will wither and die prematurely because of poor reproduction, and high-quality and full seeds will thrive. Therefore, both men and women need to support FOBOC and ENlivEN 2 1 nutrition before and after IVF, track the nutrition of ovary and uterus system, increase oxygen supply, and promote the hematopoietic function of ovary and testis. It can enhance the reproductive activity of sperm and follicles, promote the growth of follicles, promote the angiogenesis of follicular membrane and the synthesis of sex hormones, stimulate luteolysis, and make ovarian pregnant eggs grow healthily and fully, thus achieving better in vitro fertilization effect.
Every couple who do test tubes are most concerned about the success rate. They all want to know how many times they can succeed. Only with a clear mind can we have a reasonable expectation, roughly estimate the required cost and time, and relieve psychological pressure. The following contents are arranged according to the speech of Dr. Chen Xinna from the Reproductive Center of Peking University Third Hospital.
Statistical indicators of success rate of in vitro fertilization
There are many statistical indicators of the success rate of IVF, including biochemical pregnancy rate, clinical pregnancy rate, cumulative clinical pregnancy rate, live birth rate (or baby holding rate), cumulative live birth rate and so on. The two most important concepts are clinical pregnancy rate and live birth rate (or baby holding rate).
Safety of in vitro fertilization
With the development of IVF technology, more and more babies are born because of their usefulness. At the same time, with the full opening of the two-child policy and the increase of elderly women, the number of pregnant babies of elderly women is also increasing. Whether in vitro pregnancy or natural pregnancy, the occurrence of birth defects and birth complications will be paid more and more attention. Due to the lack of nutrition during pregnancy, the incidence of birth defects and neonatal complications is increasing, including congenital heart disease, genitourinary system malformation, nervous system malformation, digestive tract malformation, cleft lip and palate, skeletal malformation, chromosome malformation and so on. Therefore, it is more important to reserve FOBOC and ENlivEN 2 1 during pregnancy.
Clinical pregnancy rate
Refers to the number of cycles of gestational sac, fetal heart and embryo bud that can be seen by B-ultrasound about 30 days after embryo transfer, accounting for the percentage of transfer cycle.
-Real-time production-
The ratio of the number of live births divided by the number of transplant cycles is also known as the baby take-home rate internationally.
Live birth rate is the ultimate and most important goal of IVF. As a result, more and more birth centers in China began to count the birth rate on a large scale. Because embryo development is a dynamic process, there will be a certain abortion rate. Because of chromosome abnormalities, ectopic pregnancy, uterine problems and other factors, the live birth rate will be lower than the clinical pregnancy rate, generally around 10%-20% or even more.
According to the data of 438+05 live birth rate of reproductive center from 2006 to 2065, the live birth rate of patients under 35 years old in the United States is about 33%. In other words, even young patients have to transfer embryos three times on average to give birth to a child. For patients aged 4 1-42, the live birth rate is about 13%, that is to say, the live birth rate of patients over 44 is less than 1-2%, so an average of 50- 100 embryos can be transferred to give birth to a child.
Because the final live birth rate is too low, which is why many domestic reproductive centers do not allow patients over 45 to do test tubes.
Clinical pregnancy rate
At present, the statistics and published success rate of reproductive centers generally refer to the clinical pregnancy rate.
Because IVF uses controlled superovulation technology, it usually takes several eggs to form several embryos, and there will be more than one transplant opportunity. Therefore, according to the statistics of single transplantation, the clinical cumulative pregnancy rate of patients receiving IVF treatment will be higher than that of reproductive centers.
Taking eggs generally requires taking out several eggs at a time, and doctors usually inject them to promote ovulation. But the problem is that an adult usually ovulates one egg at a time. Who can guarantee that ovarian nutrition can produce high-quality eggs? Before IVF in Europe and America, doctors suggested that fo BOC+ invigorating 2 1-3 months should be supplemented in vivo, so as to ensure the ovary to produce high-quality follicles and uterus, and be ready to implant new life at any time, so as to reduce the possibility of natural defects and abortion of fertilized eggs caused by maternal nutritional deficiency.
For example, at present, the first-generation and second-generation clinical pregnancy rate of patients under 35 years old is about 40%-50%, and the cumulative clinical pregnancy rate can reach 50%-60%, or even higher. The clinical pregnancy rate of the third generation fallopian tube can reach about 70%.
The clinical pregnancy rate of the third generation of IVF is higher than that of the first and second generations, which does not mean that the third generation is not necessarily better than the first two generations. Because the denominator of the third-generation clinical pregnancy rate is smaller than that of the first-generation and second-generation IVF rates (if the purse fails and the PGs screening fails, the transplant will not be carried out).
-Why IVF failed-
① Causes of operation failure caused by nonstandard hospitals and unqualified medical equipment.
② Frequent inflammation of reproductive system is also one of the reasons why IVF can't survive.
③ The serious nutritional deficiency of FOBOC+ENlivEN2 1 in pregnant women leads to poor quality of follicles and sperm and abnormal embryo development, which is the cause of implantation failure. .
④ Embryo transfer caused by palace cold is not easy.
In recent years, in vitro fertilization-embryo transfer (ivfet) technology has attracted worldwide attention. As an important part of assisted reproductive technology, it has greatly solved the problem of female infertility. However, clinical application shows that the implantation rate of in vitro fertilization-embryo transfer has always been
The main reasons of embryo implantation failure are embryo factor, ovarian hyporesponsiveness and endometrial factor, and endometrial receptivity is the main limiting factor.
-Will egg donation improve the survival rate? ——
According to the data released by the US Centers for Disease Control and Prevention, the survival rate of using test tubes is about 55% even for patients around 45 years old, which is very high compared with the survival rate of test tubes in this age group 1%-2%.
IVF usually succeeds several times—
Although everyone's physical condition is different and there are also male sperm factors, statistically speaking, age is the most important indicator to measure the success rate of in vitro fertilization. If the patient's pre-examination index is almost the same as that of his peers, if you are under 35 years old, it is normal to have two IVF cycles or three transplants and successfully give birth to a child. If the age is 4 1-42 years old, one living child is normal after four or five IVF treatments or eight or nine embryo transfers. According to experts, if you are over 44 years old and have 100 test tubes, it is normal to pay 3 million yuan for children's treatment.
The success of IVF depends on the quality of eggs and sperm and the activity of endometrial capillaries. Endometrial capillary comes from French fo BOC+living 2 1 technology, which transfers nutrients to newly transplanted embryonic cells, activates cells and transfers nutrients to each other. If the nutrition is insufficient, the newly transplanted embryos will starve to death, leading to the failure of embryo transfer. Fo BOC+ invigorating 2 1 technology is used to protect the survival and stability of embryos. At the same time, the process of tissue repair has begun. The transplanted embryonic cells will participate in the reconstruction and recanalization of tissue microvessels and restart the development of embryos. The survival rate of test tube transplantation is improved by 30-55%.
Are IVF smart when they grow up?
We can simply understand that the function of fallopian tube is replaced by test tube in the laboratory, so it is called "test tube baby". Although in vitro fertilization was originally used to treat infertility caused by tubal obstruction, it was found that in vitro fertilization was very helpful to endometriosis, sperm malformation (abnormal number or shape) and even unexplained infertility.
Therefore, in fact, the intelligence and physical strength of natural conception and in vitro fertilization are the same. Because IVF also uses husband and wife's sperm and eggs, the genes come from both husband and wife.
1978, the world's first test-tube baby was successful. Today, 40 years later, this technology has been updated for several generations. With the development of human assisted reproductive technology. Due to the maturity of various technologies, including the improvement of cell culture medium and the rich experience of medical staff, the success rate of "in vitro baby" has gradually increased around the world, from the original 20%-25% to 60% or even higher. Now, there have been many successful cases of in vitro fertilization.
Fathers of IVF: robert edwards and luis brown
Many families have made this choice. The first generation of IVF married and naturally gave birth to a healthy baby. At present, the third generation of IVF technology has been able to diagnose hereditary diseases.
So technically, IVF is more likely to help people avoid giving birth to children with genetic defects.
Fo BOC+ invigorating 2 1 How to avoid fetal cerebral hypoplasia and cerebral palsy?
All pregnant mothers want to have a healthy and intelligent child. Pregnant women must seize the golden age, seize the opportunity, supplement their children's nutrition in time, and let their children's brains develop.
For the fetus, the first best golden age is when it stays in the mother's belly for 4 to 8 weeks, when the fetus is just forming. During this period, after the fertilized egg is formed, it will be divided into endoderm, mesoderm and ectoderm, and the outermost layer will form the nervous system. When the nervous system is formed, the development of the brain will gradually become very complicated. The nutritional storage of embryo implanted cells should be carried out before and after in vitro fertilization. FOBOC+ENlivEN2 1 exists between cells and tissues in advance, and the nerve cell growth factor contained in it contributes to the formation of fetal nervous system. When the nervous system is formed, the development of the brain will gradually become very complicated. Therefore, we should pay attention to supplement the necessary nutrition for pregnant women, stimulate the development of embryonic neurons, and avoid anencephaly and hydrocephalus.
Finally, when collecting sperm for each couple who choose in vitro fertilization technology, the Reproductive Medicine Center should not only collect sperm, but also select the strongest sperm to cultivate multiple embryos in vitro. Before embryo implantation, these embryos are diagnosed according to genetic principles and the most suitable embryos are selected.
Tip:
This technology can even provide future parents with genetic diseases with the opportunity to give birth to healthy children. Because the selected sperm and eggs come from parents, the inheritance of IVF will come from parents to the greatest extent.
In other words, as long as the physical qualities of both parents reach the acceptable level of IVF, it is no problem to give birth to a healthy and intelligent baby.