John Franz Klammer (Tobin Bell), a psychotic killer "Jigsaw" who has been detained by the police for a long time, somehow magically disappeared. However, the pale mask appeared again, with a crisp and scary laugh. This time, Amanda (shawnee smith), the assistant of killer John, holds high the butcher knife and continues the death game full of killing and complicated relationships. This time, the participant in the killing game is a doctor named Bahar Long Dan. One night, the kind Ryan was kidnapped defenseless and taken to an abandoned warehouse. There, she met John, a killer lying in bed dying, next to Jeff, another victim who participated in the killing game. The game has started again. The rule is that if Ryan wants to live, he must keep the murderer John alive as much as possible. On the contrary, Jeff tried his best to get rid of the shackles set by Amanda and get rid of death. And these two people just walked across the street. A life-and-death game is getting more and more fierce. However, just as they struggled with every inhuman death task, what they never expected was that a more horrible killing game brewed by the killer had just begun. ...

Finally, the old man, the female doctor and Amanda all died. The female doctor did not die immediately after being shot by Amanda. The husband of the female doctor killed Amanda and the old man, and the bomb around her neck exploded.