The cause of disease
Most patients had cytomegalovirus, EB virus or mycoplasma infection before onset, but the etiology of a few cases was unknown. The nature of the disease is not clear, which may be related to immune damage. Injecting patient's serum into animal's nerves can produce perivenous demyelinating lesions. In addition, there are C3b and immunoglobulin C (IgG or IgM) in the nerve tissue of patients. The above facts suggest that this disease may be related to humoral immunity. But so far, no antibodies against myelin protein have been extracted from patients' blood. One of the side effects of influenza A vaccine injection may be Guillain-Barre syndrome.