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Etiology of Guillain-Barre Syndrome
Guillain-Barre syndrome is a common demyelinating disease of spinal cord and peripheral nerves. Also known as acute idiopathic polyneuritis or symmetrical polyradiculitis. The clinical manifestations are progressive symmetrical paralysis, quadriplegia and sensory disturbance in different degrees. Most patients can recover completely after acute or subacute clinical course, and a few serious patients can cause fatal respiratory paralysis and bilateral facial paralysis. Cerebrospinal fluid examination showed typical protein increase and normal cell number, also known as protein cell separation.

The cause of disease

Most patients had cytomegalovirus, EB virus or mycoplasma infection before onset, but the etiology of a few cases was unknown. The nature of the disease is not clear, which may be related to immune damage. Injecting patient's serum into animal's nerves can produce perivenous demyelinating lesions. In addition, there are C3b and immunoglobulin C (IgG or IgM) in the nerve tissue of patients. The above facts suggest that this disease may be related to humoral immunity. But so far, no antibodies against myelin protein have been extracted from patients' blood. One of the side effects of influenza A vaccine injection may be Guillain-Barre syndrome.