He is currently the executive director of the Southern Research Center of the National Human Genome, and the director of the Shanghai Key Laboratory of Disease and Health Genome (the state key laboratory cultivation base jointly established by the province and the Ministry); Director of Biochip Shanghai National Engineering Research Center; Professor and Director of Department of Microbiology and Microbial Engineering, School of Life, Fudan University; Professor, Department of Microbiology, Chinese University of Hong Kong.
20 15, 1 1, won the eighth Tan Life Science Award.
Basic introduction Chinese name: Zhao Guoping Nationality: China Birthplace: Shanghai Date of Birth: 1948 Occupation: Teaching and research worker Graduation institution: Purdue University, USA Major achievements: characters experience was elected as an academician of China Academy of Sciences in 2005, major achievements, scientific research achievements, honorary recognition, social service, characters experience1969 65438+/kloc-0. Zhao Guoping 1982, Zhao Guoping graduated from the Department of Biology of Fudan University, majoring in microbiology. From 65438 to 0983, Zhao Guoping went to the Department of Biochemistry, Purdue University, Indiana, USA. 1990, Zhao Guoping received his doctorate. 1992, Zhao Guoping returned to China after completing postdoctoral research. 1992- 1994, Zhao Guoping was appointed as the production manager of Shanghai Promeg Biological Products Co., Ltd., 1995, and Zhao Guoping was appointed as the deputy director and director of the microbial secondary metabolism control laboratory of Shanghai Institute of Plant Physiology, China Academy of Sciences. From 65438 to 0996, Zhao Guoping was appointed as the deputy director of Shanghai Institute of Plant Physiology, China Academy of Sciences. Since 1996, he has been a member of the National "863" Biotechnology Expert Committee. 1February, 1997, Zhao Guoping was transferred as the director of Shanghai Bioengineering Research Center of China Academy of Sciences. 1999 In July, Zhao Guoping was transferred to Shanghai Institute of Life Sciences, Chinese Academy of Sciences, and since 1999, he has been the director of the Biotechnology Expert Committee of Chinese Academy of Sciences. In 2005, Zhao Guoping was elected as an academician of China Academy of Sciences. In 2008, Zhao Guoping was appointed as the director of the Key Laboratory of Synthetic Biology approved by China Academy of Sciences. Main scientific research achievements: the regulation of microbial metabolism, the study of structure-activity relationship and reaction mechanism of enzymes, and the development of corresponding microorganisms and engineering biotechnology in protein. He presided over a number of studies on microbial genomes and functional genomes, and completed the research on important pathogens. The whole genome sequencing and annotation of leptospira interrogans identified several key metabolic pathways and gene functions, which provided a new idea for further study of pathogenic mechanism. He presided over the molecular epidemiology of SARS and the evolution of SARS coronavirus, which laid the foundation for understanding the animal origin of the virus and the variation law of genome, especially key genes, in the process of animal transmission to human beings. While studying in the United States, researcher Zhao Guoping studied the structure and functional molecular biology of tryptophan synthetase in E.coli, completed the identification of multiple mutations in E.coli, deeply studied the β(B8) mutant subunit protein encoded by point mutation trpB8 of β subunit "hinge region", and reported the site cut by OmpT protease for the first time. After returning to China, he presided over the production of ribonuclease inhibitory proteins and other products, guided the construction of cephalosporin gene-deleted strains of GL-TACA acylase genetic engineering bacteria, and presided over the key project of National Natural Science Foundation "Molecular Mechanism of Biosynthesis Regulation of Actinomyces Secondary Metabolites". Since 1998, he has participated in hosting the special support project of human genome of China Academy of Sciences, and established the laboratory of genetic resources and genome engineering. Published academic papers 16; Training 10 master's and doctoral students. In April, 2003, a team mainly from China with French and American scientists published the results of genome sequencing, functional annotation, evolution, physiology and pathogenic mechanism analysis of leptospira in Nature. He is the leader of this three-year research work. He also participated in the genome research of fungi, Schistosoma japonicum and silkworm. Honorary recognition: 2065438+2005 10, 165438, won the eighth Tan Life Science Award. The society served as honorary chairman of chinese society for microbiology; Director of China Bioengineering Society and Chairman of Shanghai Bioengineering Society; Member of Shanghai Science and Technology Association, Vice Chairman of Pudong New Area Science and Technology Association.