The systematic study of microbial molecular ecology was first carried out in China, and a lot of innovative work was done in the analysis technology and statistical calculation method of complex microbial community structure. The widely used PCR-DGGE technology has been improved and become one of the advanced laboratories in the world to study microbial ecology by using this technology. The technical methods based on random amplified fingerprinting and molecular hybridization were innovatively established, and the community structure was analyzed and compared to find important functional bacterial genome fragments as molecular markers. People have done a lot of research on the relationship between microbial community structure and function in human and animal intestines, biochemical ponds for treating industrial wastewater, soil, oil reservoirs and other environments, and achieved remarkable results. He has published more than 20 papers in PNAS (Proceedings of the National Academy of Sciences), nrdd (Natural Review of Drug Discovery), AEM (Applied and Environmental Microbiology), ISME Magazine, BMC Bioinformatics, protein Group Research Magazine, Clinical Microbiology Magazine, Microbial Ecology, FEMS Microbial Ecology, Microbial Methods Magazine, FEMS Microbiology Express, Microbiology Magazine and Ecology Magazine, and his research work has attracted the attention of international peers. He was invited to give a keynote speech at the 8th International Symposium on Bacterial Genetics and Ecology (Lyon, France) and give a speech at the 10th International Conference on Microbial Ecology, Environmental Biotechnology Branch (Cancun, Mexico). He gave a speech at the 1 1 International Conference on Microbial Ecology, Human Microecology Branch (Vienna, Austria), and co-chaired the round-table discussion on "Sludge Metagenomics". In August 2006, he was elected as one of the executive directors of the International Society of Microbial Ecology 12. In recent years, we have actively promoted the application of the concept of systems biology in the field of microbial ecology, especially in the study of human intestinal flora, paid attention to the development of the method of combining metabonomics with metagenomics to study the role of intestinal flora in complex diseases such as obesity and diabetes, actively explored the problem of monitoring human health changes and evaluating the efficacy of traditional Chinese medicine based on the overall structural changes of intestinal flora, and began to form a new direction of human system biology with metagenomics as the core.