You can't absolutely say yes or no. If you submit your resume and don't plan to go for an interview, you'd better contact the other company and explain why you can't go. This is basic courtesy, so that the company will at least not leave you a bad impression, at least it will not affect your possibility of investing in this company in the future.

As for not going to the interview many times, it is reasonable to say that it will not affect the job search in the future. At least not yet.