Guo 1987 graduated from the University of Minnesota with a doctorate in microbiology and genetics. 1990 completed the postdoctoral research of NIH and began to work at Purdue University. 1993 was hired as a tenured professor by Purdue University. 1997 was a full professor of molecular virology at Purdue University. Since 2007, she has been employed as the chairman of Dane and Mary Louise Miller in biomedical engineering at the University of Cincinnati, and served as the director of the Center for Nanomedicine at the National Institutes of Health (NIH). 20 12 has been employed as Professor William S. Farish from College of Pharmacy, University of Kentucky since June. At the same time, he served as the director of the nanotechnology cooperation project of the Cancer Institute of the National Institutes of Health (NIH), and presided over the research of projects such as "RNA nanotechnology and cancer treatment".