At the beginning of the school, the school shouldered the heavy responsibility of "resisting Japan and saving the country" and was an important stronghold of underground organizations in southeast and Guangxi. At that time, famous teachers gathered and students were excellent. It was one of the most influential schools in the history of education in Guangxi. Domestic celebrities such as Li, He Xiangning, Liang Shuming, Chen Bensheng, Qian Jiaju, Liu Yazi, Zhang Tiesheng and Mo Naiqun. All have carried out democratic anti-Japanese propaganda or organization work here.
Hezhou High School was founded in 1940. Its predecessor was private Linjiang Middle School founded by Hu Tianle and Huang, and it was successively called Hexian Fanglin Middle School, Linjiang Middle School, Hexian Senior Middle School and Hezhou Senior Middle School. In 2003, the school was placed under the jurisdiction of Hezhou City, and was designated as a key high school in Hezhou City, renamed as "Hezhou Senior High School". In 2005, it passed the acceptance evaluation and became a model ordinary high school in the autonomous region. 20 1 1 year, the municipal party Committee and the municipal government decided to relocate Hezhou senior high school, and the government invested 400 million yuan to build a new campus of Hezhou senior high school. From 2065438 to September 2004, Hezhou High School was successfully relocated and expanded, which ushered in a new era of scientific development.