Long-term commitment to clinical and experimental research of cardiovascular diseases in internal medicine, especially in the fields of cardiac catheterization, acute subendocardial myocardial infarction, water-electrolyte balance of congestive heart failure, artificial cardiac pacing and the pathogenesis of arrhythmia. , has made outstanding achievements, obtained a number of scientific and technological achievements, and reached the domestic leading level. In the middle and late 1950s, he was engaged in the research on subendocardial myocardial infarction, Pedra myocarditis and paroxysmal tachycardia. Among them, 1958 reported subendocardial myocardial necrosis for the first time in China with a series of cases, which changed the concept of myocardial infarction site in China and was of great significance, attracting the attention of scholars at home and abroad. As early as 1950s, Professor Shi was engaged in cardiac catheterization in Tianjin. In the early 1960s, the author made a systematic study on congestive heart failure and water-electrolyte imbalance, and put forward his own unique viewpoint, which was highly valued by scholars at home and abroad and had great clinical value. Since 1970s, we have devoted ourselves to the clinical and experimental research of arrhythmia, established the clinical electrophysiology laboratory, and established the whole and isolated cardiac electrophysiology, myocardial cell action potential, voltage clamp and patch clamp experimental research. Since then, other research methods such as His bundle electrogram, sinoatrial node electrogram and atrioventricular programmed stimulation have been applied to clinic in China. Professor Shi Yuzhu has published more than 0/00 papers on arrhythmia and electrophysiology, including more than 0/00 papers on "dual atrioventricular nodal pathways and paroxysmal supraventricular tachycardia". Professor Shi is one of the pioneers of artificial heart pacing in China. Implantable pacing was introduced and carried out in Beijing, Tianjin and Hebei and Ningxia in the early 1970s. 1975 was reported for the first time in China, and it was confirmed by pathology as Levs disease.