Zhu Liangzu was a militia marshal in the Yuan Dynasty. Defeated by Zhu Yuanzhang many times, he was captured and surrendered. He took part in the Ming army's battle to attack and destroy Chen Youliang, Zhang Shicheng, Fang Guozhen, Mingxia and other regimes, and as the main force of the Ming army, he put down Guangdong and Guangxi. Hongwu three years (1370), sealed Yongjia Hou. During his stay in Guangdong, he colluded with local strongmen, which led to Zhu Yuanzhang's unjust murder of Panyu County magistrate Daotong, and was finally discovered by Zhu Yuanzhang.
In September of the 13th year of Hongwu (1380), Zhu Liangzu was recalled to the capital, flogged to death with his eldest son Zhu Xian, and his title was abolished. Later, he was regarded as an anti-party member by Hu.